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Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Overview of attention for article published in Journal of Translational Medicine, July 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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10 tweeters
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1 Facebook page

Citations

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24 Dimensions

Readers on

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43 Mendeley
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Title
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Published in
Journal of Translational Medicine, July 2016
DOI 10.1186/s12967-016-0966-x
Pubmed ID
Authors

Estela G. Toraño, Gustavo F. Bayón, Álvaro del Real, Marta I. Sierra, María G. García, Antonella Carella, Thalia Belmonte, Rocío G. Urdinguio, Isabel Cubillo, Javier García-Castro, Jesús Delgado-Calle, Flor M. Pérez-Campo, José A. Riancho, Mario F. Fraga, Agustín F. Fernández

Abstract

Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role in the process. Here, we analyzed the genome-wide profile of 5hmc in mesenchymal stem cells (MSCs) obtained from bone-marrow donors, aged 2-89 years. We identified 10,685 frequently hydroxymethylated CpG sites in MSCs that were, as in other cell types, significantly associated with low density CpG regions, introns, the histone posttranslational modification H3k4me1 and enhancers. Study of the age-associated changes to 5hmC identified 785 hyper- and 846 hypo-hydroxymethylated CpG sites in the MSCs obtained from older individuals. DNA hyper-hydroxymethylation in the advanced-age group was associated with loss of 5mC, which suggests that, at specific CpG sites, this epigenetic modification might play a role in DNA methylation changes during lifetime. Since bone-marrow MSCs have many clinical applications, and the fact that the epigenomic alterations in this cell type associated with aging identified in this study could have associated functional effects, the age of donors should be taken into account in clinical settings.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 30%
Professor 4 9%
Student > Ph. D. Student 4 9%
Student > Doctoral Student 4 9%
Student > Postgraduate 3 7%
Other 9 21%
Unknown 6 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 33%
Medicine and Dentistry 7 16%
Agricultural and Biological Sciences 7 16%
Engineering 3 7%
Computer Science 2 5%
Other 2 5%
Unknown 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2016.
All research outputs
#1,283,872
of 8,155,605 outputs
Outputs from Journal of Translational Medicine
#215
of 1,816 outputs
Outputs of similar age
#57,400
of 260,249 outputs
Outputs of similar age from Journal of Translational Medicine
#7
of 97 outputs
Altmetric has tracked 8,155,605 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,816 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.