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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
|
|---|---|
| Published in |
Journal of Cardiovascular Translational Research, July 2016
|
| DOI | 10.1007/s12265-016-9705-1 |
| Pubmed ID | |
| Authors |
Janine C. Deddens, Krijn R. Vrijsen, Johanna M. Colijn, Martinus I. Oerlemans, Corina H. G. Metz, Els J. van der Vlist, Esther N. M. Nolte-’t Hoen, Krista den Ouden, Sanne J. Jansen Of Lorkeers, Tycho I. G. van der Spoel, Stefan Koudstaal, Ger J. Arkesteijn, Marca H. M. Wauben, Linda W. van Laake, Pieter A. Doevendans, Steven A. J. Chamuleau, Joost P. G. Sluijter |
| Abstract |
Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 33% |
| Australia | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 25% |
| Researcher | 14 | 13% |
| Student > Bachelor | 11 | 10% |
| Student > Master | 7 | 7% |
| Professor | 6 | 6% |
| Other | 19 | 18% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 28% |
| Biochemistry, Genetics and Molecular Biology | 21 | 20% |
| Agricultural and Biological Sciences | 9 | 8% |
| Engineering | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 30 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#7,767,115
of 24,909,203 outputs
Outputs from Journal of Cardiovascular Translational Research
#204
of 638 outputs
Outputs of similar age
#120,680
of 363,644 outputs
Outputs of similar age from Journal of Cardiovascular Translational Research
#6
of 9 outputs
Altmetric has tracked 24,909,203 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 638 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,644 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.