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Animal Cell Technology: Products from Cells, Cells as Products

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Cover of 'Animal Cell Technology: Products from Cells, Cells as Products'

Table of Contents

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    Book Overview
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    Chapter 1 Recombinant Pharmaceutical Protein Overexpression in an IRF-1 Proliferation Controlled Production System
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    Chapter 2 The Real Meaning of High Expression
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    Chapter 3 A Novel Mammalian Gene Regulation System Responsive to Streptogramin Antibiotics
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    Chapter 4 Feedback Control of Redox Potential in Hybridoma Cell Culture
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    Chapter 5 Genetic Manipulation of the Protein Synthetic Capacity of Mammalian Cells
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    Chapter 6 Retinoic Acid Enhances Monoclonal Antibody Production of Human-Human Hybridoma BD9
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    Chapter 7 Extracellular Adenosine 5’ Monophosphate Controls Proliferation and Stimulates Protein Production of rCHO Cells
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    Chapter 8 The Mode of Actions of Lysozyme as an Immunoglobul in Production Stimulating Factor (IPSF)
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    Chapter 9 A Dissection of Recombinant Protein Expression in CHO Cells Indicating Protein-Specific, not Cells Specific, Limitation
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    Chapter 10 Effect of Bioreactor Process Control Parameters on Apoptosis and Monoclonal Antibody Production During the Protein-Free Fed-Batch Culture of a Murine Myeloma
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    Chapter 11 Adenovirus Vector Production in 293 Fed-Batch Cultyres
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    Chapter 12 Influence of BCL-2 Over-Expression on NS0 and CHO Culture Viability and Chimeric Antibody Productivity
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    Chapter 13 A Regulatable Selective System Facilitating Isolation of High Expression Mammalian Cells
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    Chapter 14 Comparative Analysis of IRES Efficiency of Dicistronic Expression Vectors in Primary Cells and Permanent Cell Line
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    Chapter 15 Use of Gel Microdrops Selection System for Recombinant Cells
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    Chapter 16 Bovine Serum-Albumin with Grafted RGD Tailed Cyclic Peptudes as an Engineered Proadhesive Protein
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    Chapter 17 Matrix Attachment Regions in Stable CHO Cell Line Development
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    Chapter 18 High Cell Density Cultivation of Hybridoma Cells: Spin Filter vs Immobilized Culture
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    Chapter 19 Influence of the Inoculum on the Production of Antibodies with Mammalian Cells
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    Chapter 20 Establishing and Developing Cho Cell Lines for the Commercial Productoin of Human Anti-Rhesus D IgG
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    Chapter 21 Glucose and Glutamine Replacement for the Enhancement of Fed-Batch Processes Using CHO Cells
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    Chapter 22 Pilot Scale Production of Human Prothrombin Using a Recombinant CHO Cell Line
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    Chapter 23 Maintenance of High Viability During Direct Transition of CHO-K1 Cell Growth from 10% to 0% Serum; No Adaptation Required
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    Chapter 24 Analysis and Simultaneous Isolation of Recombinant t-PA Using High Performance Membrane Affinity Chromatography
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    Chapter 25 Improvement of the Primary Metabolism of Cell Cultures Introducing a Pyruvate Carboxylase Reaction Pathway
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    Chapter 26 Growth Kinetic Studies (In Hours) Based on the Fluorescence of Stable, GFP-Expressing CHO Cells
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    Chapter 27 Intracellular Localization of Non-Secreted Recombinant β-Trace Protein in Vesicle-Like Structures of Baculovirus-Infected Insect Cells
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    Chapter 28 Induction Kinetics of Apoptosis in Mammalian Cell Cultures
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    Chapter 29 A Model for the On-Line Scrutiny of Metabolism: Its Application to the Changing Nutritional Demands of Cultured Animal Cells
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    Chapter 30 Caspases as a Target for Apoptosis Inhibition in Hybridoma Cells in Culture
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    Chapter 31 Cell Activity After Cell Growth Inhibition by the IRF-1 System
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    Chapter 32 Establishment of a Pramary Liver Cell Culture from a Teleost, Oreochromis Mossambicus, the Tilapia: a Valid Tool for Physiological Studies
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    Chapter 33 TGF-β Induces Premature and Replicative Senescence in Cancer Cells
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    Chapter 34 Development of a Fed-batch Strategy That Utilizes Multiple Carbon Sources to Maximize Recombinant Protein Eepression in CHO Cells
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    Chapter 35 Development of a New, Highly Flexible, Fully Computer Integrated Fermentor Control System
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    Chapter 36 Cell Growth Rate Estimation in Packed-Bed and Hollow Fibers Bopreactprs: Metabolism and Productivity
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    Chapter 37 Influence of Oxygen Limitation on Myeloma Cell Cultures
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    Chapter 38 Comparison of Fed-batch Strategies in Hybridoma Cultures
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    Chapter 39 Non-Invasive Adaptive Control of the Feed Rate for High Cell Density CHO Cultures According to the pO2 Profile
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    Chapter 40 Cell Growth Control by the IRF-1 System in Perfusion Culture
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    Chapter 41 Modulation of Cell Cycle for Optimal Recombinant Protein Production
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    Chapter 42 Application of Bioassays for Suspended 293 Cell Enumerations in Chemically Defined Medium (CDM)
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    Chapter 43 Efficient Cell Growth by an Optimised Protein Free Medium Design and a Controlled Feeding Strategy
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    Chapter 44 Development of a Serum Free Meditum for a Human Diploid Fibroblast Cell Line
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    Chapter 45 The Use of Peptones as Medium Additives for High-Density Perfusion Cultures of Animal Cells
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    Chapter 46 Determination of Animal Cell Densities and Viabilities by the New Analyser CEDEX2
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    Chapter 47 Determination of Cell Numbers and Viability; Comparison of the Microcyte Flow Cytometer with Trypan Blue Counts and Coulter Counts
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    Chapter 48 Mid-Infrared Spectroscopic Monitoring of Animal Cell Culture Bioreactor Processes
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    Chapter 49 Mammalian Cell Monitoring Using the Microcyte Flow Cytometer
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    Chapter 50 Indirect Biomass Determination in Case of Con-Constant Metabolic Rates
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    Chapter 51 Whole Cell-Smart Microsensor: A first Approach Towards Interfacing Live Cells and Electronics
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    Chapter 52 Comparison of Immobilised Group Specific Affinity Ligands for the Bioseparation of Antibodies by High Performance Membrane Affinity Chromatography
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    Chapter 53 Posttranslational Modifications Limit High Level Expression of Functionally Active Chimeric P-Selectin Glycoprotein Ligand-1 in rCHO Cells
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    Chapter 54 Glycosylation Analysis of Nanomolar Amounts of Glycoprotein Combining In-gel Enzymatic Digestion and FACETM
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    Chapter 55 Glycosylation Patterns of a rec-Fusion Protein Expressed in BHK Cells at Different Metabolic States
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    Chapter 56 Elimination of N-Glycolylneuraminic Acid Residues in Recombinant Glycoproteins: A Gene Knock-Out Approach
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    Chapter 57 Fucosyltransferase III Production by Mammalian and Insect Cells for the Synthesis of Therapeutic Oligosaccharides
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    Chapter 58 Control of Therapeutic Monoclonal Antibody Glycosylation
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    Chapter 59 The Effect of Cell Line, Transfection Procedure and Reactor Conditions on the Glycosylation of Recombinant Human Anti-Rhesus D IgGl
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    Chapter 60 Metabolic Engineering of Recombinant Plasminogen Sialylation in Animal Cells by Tetracycline-Regulated Expression of Murine CMP-NeuAc Synthetase and Hamster CMP-NeuAc Transporter Genes
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    Chapter 61 Air-Trap-Technology: Bubble-Free Gas Transfer in Large Scale
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    Chapter 62 The Improvement of Aeration in 8000 I Animal Cell Culture Vessels
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    Chapter 63 A Novel Continuous Suspension Culture System for Hematopoietic Cells
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    Chapter 64 Large Scale Production of HIV-I gp120 Using Recombinant Vaccinia Virus in Packed-Bed Bioreactor
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    Chapter 65 The “Shear Tester”
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    Chapter 66 Membrane Oxygenation of Mammalian Cell Culture Fermenters Using Dupont Teflon AF-2400 Tubing
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    Chapter 67 Configuration of a Simple Dialysis Membrane Bioreactor Suitable for Large-Scale Application
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    Chapter 68 Erythropoietin Production from CHO Cells Grown in a Fluidized-Bed Bioreactor with Macroporous Beads
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    Chapter 69 Scale-Up of Fixed-Bed Reactors for the Cultivation of Animal Cells
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    Chapter 70 A Novel Conical Shaped Bioreactor for Small-Scale Investigations Under Defibed Conditions
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    Chapter 71 Continuous Perfused Fluidized Bed Technology
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    Chapter 72 Small Scale Bioreactor System for Process Development and Optimization
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    Chapter 73 Mammalian Transient Gene Expression-Potential, Practical Application and Perspectives
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    Chapter 74 Float! — And Express More
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    Chapter 75 Multiplicity and Time of Infection as Tools to Maximize Virus-Like Particle Production by Insect Cells
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    Chapter 76 Process Development for Transient Gene Expression in Mammalian Cells at The 3 L Scale: 10–50 MG of R-Protein in Days
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    Chapter 77 A Method to Determine the Optimal Time to Infect Insect Cells with the Baculovirus Expression System
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    Chapter 78 Analysis of Baculovirus Infected Sf9 Cells Using Flow Cytometry
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    Chapter 79 Adaptation of Recombinant HEK-293 Cells to Growth in Serum Free Suspension
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    Chapter 80 Growth on Microcarriers and Nutritional Needs of High Density Insect Cell Cultures
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    Chapter 81 Use of Flow Cytometry in the Evaluation of Hydroxyapatite for the Purification of Plasmid DNA
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    Chapter 82 Regulation and Standardi Sation of Gene Transfer Products in the European Union
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    Chapter 83 Study of Stability of Expression of a Humanized Monoclonal Antibody from a Transfected NSO Myeloma Cell Line Using Different Culture Media and Serum Concentrations
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    Chapter 84 Analysis of Alterations in Gene Expression after Amplification of Recombinant Genes in CHO Cells
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    Chapter 85 Stable Recombinant Expression and Functinal Identity of the Anti HIV-I Monoclonal Antibody 2F5 after IGG3/IGGI Subclass Switch in CHO-Cells
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    Chapter 86 Analysis of Genomic DNA and RNA-Transcripts of a Heterohybridoma SDNA imultanously Expressing IgG3 and IgG1 with Identical Specificity
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    Chapter 87 Tissue Engineering of a Bladder Wallpatch
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    Chapter 88 Integrated Optimization of Retrovirus Production for Gene Therapy
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    Chapter 89 Toxicological Evaluation of Surface Water Samples in Sensitized Cultured Fish Cells, and Comparison with the Microtox00AE; Method
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    Chapter 90 Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes
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    Chapter 91 Study of DDS for a Cancer Therapy Applying Lipid Vesicle Immobilizing Eucheuma Serra Lectin
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    Chapter 92 Study of the Specific Binding between Lipid Vesicles and Human-Human Hybridoma toward Eitger DDS or Gene Transfection
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    Chapter 93 Suppression of Apoptosis in UV-Damaged Human Melanomacells by a Fermented Milk, Kefir
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    Chapter 94 Large Scale GMP Production of Retroviral Gene Therapy Vectors in Vert Low Serum Medium
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    Chapter 95 Chimeric Lyssavirus Glycoprotein: New Vector for Multivalent Vaccines
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    Chapter 96 The SPP Biotech Module 1: Proteins for Medical Applications a Multidisciplinary Effort for the Development of a Recombinant Anti-RhD Antibody Preparation of Hemolytic Disease of the Newborn
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    Chapter 97 Low Serum and Serum-Free Cultivation of Mammalian Cells Used for Virus Production Applications
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    Chapter 98 Development of a Serum-Free Medium for MRC-5 Culture
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    Chapter 99 Adaptation of Vero Cells to a Serum Free Medium for the Production of Rabies Virus
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    Chapter 100 Increased Productivity of a Rickettsia Vaccine: Enhancement of Adhesion Properties of Infected Endhothelial Cells by TGFβ
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    Chapter 101 Comparative Study of Cell Cultures Perspective for Rubella Virus Production
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    Chapter 102 Biogenesis of Epithelial Phenotype During Long-Term Cultivation of MDCK Cells in Serum-Free Ultra-MDCK Medium
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    Chapter 103 Sandwich Elisa Today: Limits for Sensitivity, Speed, Precision and Throughput
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    Chapter 104 Impact of ICH Guidelines on Phases of Development of Biotechnology Products
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    Chapter 105 The Microbial Risks of Xenotransplantation
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    Chapter 106 Cryopreservation under Protein-Free Medium Conditions: A Reliable Way to Safe Cell Banking
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    Chapter 107 Creation of Certified Cell Banks Suitable for Production of Healing and Immunobiological Preparations
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    Chapter 108 Endogeneous Retrovirus Particles and Their Eeffcts on the Growth Behavior of Hybridoma Cultivation Processes
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    Chapter 109 Testing for Adventitious Retroviruses Using PCR-Based Revese Transcriptase Assays
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    Chapter 110 Rapid RNA Quantitation from Xenotropic SP2/0 Retroviruses by Competitive RT-PCR ELISA
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    Chapter 111 Human Amniotic Epithelial (HAE) Cells Express Erythropoietin (EPO) and EPO-Receptor
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    Chapter 112 The Nordenau-Phenomenon—Facts and Hypotheses
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    Chapter 113 Conversion of a Process Development Pilot Plant into a Clinical Phase I/II Manufacturing Facility for Recombinant Proteins Expressed in Mammalian Cells
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    Chapter 114 Human Keratinocyte Culture on Macroporous Carries at the Air-Liquid Interface
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    Chapter 115 Comparison of Viability and Function of Primary Cells with Transformed Cellsfor use in a Bioartificial Liver Support System
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    Chapter 116 Determining Optimal Transport Conditions of In Vitro Cultured Human Chondrocytes Prepared for Autologous Re-Implantation Using Flow Cytometry
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    Chapter 117 Effects of Collagenase on Human Hematopoietic Cells
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    Chapter 118 Validation of the CACO-2 Test for Intestinal Permeability Assessment of Drugs: The Usefulness of PAPP, the Apparent Permeability Coefficient
Attention for Chapter 90: Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes
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Chapter title
Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes
Chapter number 90
Book title
Animal Cell Technology: Products from Cells, Cells as Products
Published by
Springer Netherlands, January 2002
DOI 10.1007/0-306-46875-1_90
Book ISBNs
978-0-7923-6075-9, 978-0-306-46875-9

M. Oda, K. Kusumoto, K. Teruya, T. Hara, T. Maki, S. Kabayama, Y. Katakura, K. Otsubo, S. Morisawa, H. Hayashi, Y. Ishii, S. Shirahata


A. Bernard, B. Griffiths, W. Noé, F. Wurm

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Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 40%
Lecturer 1 20%
Researcher 1 20%
Unknown 1 20%
Readers by discipline Count As %
Environmental Science 1 20%
Agricultural and Biological Sciences 1 20%
Chemistry 1 20%
Unknown 2 40%