@spontonic 1) Maybe you've seen this fairly recent study from Takeda? They seem to claim the same effect from a mAb they generated (competing program?). If dosed high enough, an active amount of mAb makes it through the BBB. https://t.co/98E21XFFWM
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RT @FrontNeurosci: New Research: Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation: Progranulin (PGRN) haploin…
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New Research: Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation: Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This… https://t.co/7Ls