Title |
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
|
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Published in |
Journal of Neuroscience Research, July 2016
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DOI | 10.1002/jnr.23802 |
Pubmed ID | |
Authors |
Nikita N. Burke, David P. Finn, Brian E. McGuire, Michelle Roche |
Abstract |
A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical maltreatment, an increasing number of studies have been published over the past few years examining the effect of childhood psychological stress and trauma on the development of various types of chronic pain conditions. We review the clinical and preclinical data examining the link among early-life psychological stress, altered nociceptive behavior, and chronic pain in later life. Evidence supporting a role for certain key neurobiological substrates, including the hypothalamic-pituitary-adrenal axis; monoaminergic, opioidergic, endocannabinoid and immune systems; and epigenetic mechanisms in the association between early-life psychological stress and chronic pain, is provided. Greater understanding of the impact of early-life stress may inform the development of personalized treatments for chronic pain in later life and strategies to prevent its onset in susceptible individuals. © 2016 Wiley Periodicals, Inc. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 19 | 24% |
United States | 10 | 13% |
Ireland | 5 | 6% |
Canada | 3 | 4% |
Switzerland | 3 | 4% |
Netherlands | 2 | 3% |
Spain | 2 | 3% |
Japan | 1 | 1% |
Central African Republic | 1 | 1% |
Other | 8 | 10% |
Unknown | 26 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 52 | 65% |
Scientists | 17 | 21% |
Practitioners (doctors, other healthcare professionals) | 9 | 11% |
Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 340 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 57 | 17% |
Student > Master | 46 | 13% |
Student > Ph. D. Student | 38 | 11% |
Researcher | 37 | 11% |
Student > Doctoral Student | 29 | 8% |
Other | 61 | 18% |
Unknown | 74 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 68 | 20% |
Medicine and Dentistry | 57 | 17% |
Neuroscience | 31 | 9% |
Nursing and Health Professions | 29 | 8% |
Agricultural and Biological Sciences | 14 | 4% |
Other | 49 | 14% |
Unknown | 94 | 27% |