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Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis

Overview of attention for article published in BMC Research Notes, July 2015
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Title
Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis
Published in
BMC Research Notes, July 2015
DOI 10.1186/s13104-015-1244-3
Pubmed ID
Authors

Francesco Checchi, Sebastian Funk, Daniel Chandramohan, Daniel T Haydon, François Chappuis

Abstract

The duration of the stages of HAT is an important factor in epidemiological studies and intervention planning. Previously, we published estimates of the duration of the haemo-lymphatic stage 1 and meningo-encephalitic stage 2 of the gambiense form of human African trypanosomiasis (HAT), in the absence of treatment. Here we revise the estimate of stage 2 duration, computed based on data from Uganda and South Sudan, by adjusting observed infection prevalence for incomplete case detection coverage and diagnostic inaccuracy. The revised best estimate for the mean duration of stage 2 is 252 days (95% CI 171-399), about half of our initial best estimate, giving a total mean duration of untreated gambiense HAT infection of approximately 2 years and 2 months. Our new estimate provides improved information on the transmission dynamics of this neglected tropical disease in Uganda and South Sudan. We stress that there remains considerable variability around the estimated mean values, and that one must be cautious in applying these results to other foci.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 19%
Lecturer 3 19%
Researcher 3 19%
Student > Ph. D. Student 2 13%
Professor > Associate Professor 2 13%
Other 3 19%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Agricultural and Biological Sciences 4 25%
Biochemistry, Genetics and Molecular Biology 3 19%
Mathematics 1 6%
Unspecified 1 6%
Other 2 13%