RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal immune response in convalescent or vaccinated people, can evolve to escape herd immunity and antibody treatment. https://t.co/KZ3YL
@ARanganathan72 ye kya locha hai? Please explain. https://t.co/DO0XvUkHvA
"The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants shoul
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
Here’s the preprint: https://t.co/BrBRfjTOWU
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/hIgVPO5v4X
Otro estudio ha visto la capacidad del #SARS_CoV_2 in vitro (es decir, en placa 🧫) de mutar y escapar de anticuerpos provinientes de suero altamente neutralizante. Habrá que esperar más evidencias, pero hay que estar atentos ante las nuevas variantes. h
RT @dazult_pdempsey: @marietcasey @astaines @casso69 Here's the next unpleasant surprise after E484k. https://t.co/cgZEawhhCQ E484k mutatio…
RT @dazult_pdempsey: @marietcasey @astaines @casso69 Here's the next unpleasant surprise after E484k. https://t.co/cgZEawhhCQ E484k mutatio…
@marietcasey @astaines @casso69 Here's the next unpleasant surprise after E484k. https://t.co/cgZEawhhCQ E484k mutation arises in controlled experiment , but two more concerning (from reinfection point of view) mutations arise a few generations later.
RT @Williams_T_C: what has been shown now for the first time in an elegant paper by @e_andreano, @McLellan_Lab & colleagues @biorxivpreprin…
RT @masahirono: ウイルスは免疫のはたらきをすりぬける変異を獲得しうる(免疫回避)。英・南アの変異株は、免疫不全患者が回復者血清等で治療される中で免疫回避の変異を獲得した可能性があり、これを試験管内で再現した実験で意義深い。3箇所の変異で複数の抗体に耐性は、変異株…
普通のコロナは回復血漿効くけど、南アフリカのは効かない、みたいな報道絶対日本でなされる。 回復血漿は効かないってエビデンスばっかり出てますからね SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/yCl4HuZi5n
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
@Nadav_Eyal הנזק שגרם #וריאנט_לונדון אדיר, בגלל שהוא מעלה את מקדם ההדבקה ולכן גם את רף חסינות העדר, איבדנו סופית את הסיכוי להגיע לחסינות עדר ללא חיסון מאושר עבור בני 16 ומטה. חוץ מזה, ניסויים ממוקדים במעבדה הראו שהקורונה מסוגלת לייצר וריאנט עוקף חיסונים.
RT @MarkQuarter: SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma [12-2020. Monoclonal Antibody Discovery…
RT @MarkQuarter: " plasma fully neutralized virus for 7 passages but after 45 days, deletion of F140 in spike N-terminal domain (NTD) N3 lo…
RT @Martin_Moder: Ein starkes Argument gegen den Vorschlag, zwischen beiden Impfdosen längere Zeit vergehen zu lassen: Anhaltender Selektio…
RT @McLellan_Lab: SARS-CoV-2 escape from potent neutralizing patient serum required only 3 changes: deletion and insertion in two NTD loops…
@TurloughDownes @ConorGallaghe_r This is another interesting related experiment https://t.co/cgZEawhhCQ . In a lab generated the E484K mutation ("South African" variant) and two more mutations slightly later look more concerning again (though not observed
@yvesbourdillon En laboratoire, des chercheurs ont fait émerger un variant résistant aux anticorps après avoir mis le coronavirus en contact avec du plasma de patient guéri. Seul 3 mutations ont été nécessaires. Le variant Sud Africain en contient déjà un
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
@renegade907 @DrEricDing @K_G_Andersen Yeah, him and these 18 jerks! https://t.co/HXyGCswWei With their stupid examples and experiments like NERDS!
I really hope I am reading this wrong, but it looks to me like not only will the new mutations escape immunity, that the virus didn’t require chronic infection in an immunocompromised patient. 1/8 Petri dishes mutated in the presence of robust antibodies h
RT @icp456: @EricTopol Here is a paper on lab-generated emergence of covid-19 resistance to antibodies. I believe a "glycan sequon" is an…
RT @aascarpellini: SARS-CoV2 WT: After 12 passages+80 days of plasma/virus co-incubation glutamic acid in pos 484 RBD was substituted with…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
RT @blogdopannunzio: Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a varian…
Leiam com atenção esse trabalho que a @bollemdb antecipou e que dá a medida da preocupação dos cientistas com a variante 'brasileira' encontrada em Manaus. https://t.co/wx55WfnPNe
@DrEricDing @K_G_Andersen And then there is this paper which is highly concerning. Looks to me like vaccination will not be effective and rather will simply change the dominant strain to one of these mutations that evade the immune response. https://t.co/
RT @RommieAmaro: New collab with @e_andreano @McLellan_Lab @LCasalino88 shows 3 mutations in #SARSCoV2 spike: E484K in RBD, F140 NTD deleti…
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma [12-2020. Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy. et al.] https://t.co/DV01nAREAe
" plasma fully neutralized virus for 7 passages but after 45 days, deletion of F140 in spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in receptor-binding domain (RBD) occurred" https://t.co/DV01nAREAe
RT @e_andreano: Thank you very much to @nature and the @HumanVacProject for citing our work on the SARS-CoV-2 escape mutant! https://t.co/…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @jbloom_lab: @e_andreano @RommieAmaro @McLellan_Lab selected virus w E484K (+ more muts) that was 300-fold more resistant to one human s…
RT @eclemence: #Variant #covid : le SARS-CoV-2 est un champion de la survie et de la mutation qui lutte sans cesse jusqu’à trouver des comb…
@ngbpadel2 @BeatrizCallGero @ldpsincomplejos @eslamananadeFJL @jlsteeg @diazvillanueva Y que opinas de esto? https://t.co/AuiHHzQ2jQ
RT @keyaki1117: 昨年末12月28日発表新型コロナウイルスの免疫応答回避メカニズム論文は↓ https://t.co/0id92HENDj invitroではコロナ回復者から採取の血漿とコロナウイルスを共培養。 血漿は7継代ウイルスを完全中和したが、73日目にE…
@DrErkurt Anlamadım, nasıl boş hipotez? Sizin boş hipotez dediğiniz riskin varlığı in vitro gösterildi: https://t.co/HFiLMUkICJ
RT @jbloom_lab: @e_andreano @RommieAmaro @McLellan_Lab selected virus w E484K (+ more muts) that was 300-fold more resistant to one human s…
RT @LucianoCSantos: Resumo em uma frase: Três mutações permitiram que o SARS-CoV-2 evitasse a resposta do anticorpo policlonal de um plasma…
Resumo em uma frase: Três mutações permitiram que o SARS-CoV-2 evitasse a resposta do anticorpo policlonal de um plasma convalescente COVID-19 altamente neutralizante.
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
@PeterKolchinsky Escaping At least in vitro but very likely in Vivo as well... https://t.co/XWtiAMQLeC more concerning that current treatments&vaccines may exacerbate mutations
Fonte: https://t.co/qyc343IkUR
@RodrigoMaia se a revisão for positiva para o que traz o conteúdo, O IMPEACHMENT SAI OU NÃO?! https://t.co/6Ks5jIn5M8
@oatila @oatila , por favor, você pode dar uma opinião sobre o print desse edtudo? Obrigada. https://t.co/Jv7RDAYcxF
Extremamente preocupante, novas variantes escapando anticorpos in vitro
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @jbloom_lab: @e_andreano @RommieAmaro @McLellan_Lab selected virus w E484K (+ more muts) that was 300-fold more resistant to one human s…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
SARS-CoV2 WT: After 12 passages+80 days of plasma/virus co-incubation glutamic acid in pos 484 RBD was substituted with a lysine (E484K). The mutation occurred in 100% of sequenced virions - Well, it seems ban travel to Brazil is not enough to ban E484K
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @EsterLzaro1: La pregunta ahora es si esto afectará a la efectividad de las vacunas. También me causa inquietud que las tres mutaciones…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @MichiWagner4: Schon ein paar Tage alt, aber sehr lesenswert. "The recent emergence in the UK and South Africa of natural variants wit…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @MichiWagner4: Schon ein paar Tage alt, aber sehr lesenswert. "The recent emergence in the UK and South Africa of natural variants wit…
RT @jbloom_lab: @e_andreano @RommieAmaro @McLellan_Lab selected virus w E484K (+ more muts) that was 300-fold more resistant to one human s…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
@paulodiniz90 Acredito que seja esse aqui, Paulo https://t.co/rws7QNm3nm
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @MichiWagner4: Schon ein paar Tage alt, aber sehr lesenswert. "The recent emergence in the UK and South Africa of natural variants wit…
Schon ein paar Tage alt, aber sehr lesenswert. "The recent emergence in the UK and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response" Große Ausbrüche, mehr Mutationen
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @jbloom_lab: Heterogeneity also shown by @e_andreano @RommieAmaro @McLellan_Lab, who found multiple mutations that greatly (300-fold) re…
RT @jbloom_lab: These results broadly consistent w other studies that selected RBD mutations that greatly reduce neut by polyclonal sera. S…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…
RT @DrTomFrieden: New variants are a shot across the bow: the virus can become much more dangerous. Scary study: “SARS-CoV-2 has the potent…