Antikor tedavisi ile #coronavirus mutasyonlarının evrimleşmesi ve #COVID19 antikorlarından kaçabilmesi ile ilişkili daha önce de bilgi paylaşmıştık. https://t.co/zlXV4XtEns
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma | bioRxiv https://t.co/OqwbCC7PWV @wherepond https://t.co/mrfnNJaVAw
RT @DJSiri: @EricTopol @nature @GuptaR_lab SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co…
RT @McLellan_Lab: SARS-CoV-2 escape from potent neutralizing patient serum required only 3 changes: deletion and insertion in two NTD loops…
RT @DJSiri: @EricTopol @nature @GuptaR_lab SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co…
@EricTopol @nature @GuptaR_lab SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/mrfnNJaVAw
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/FMTB0D5Ias
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/MWUuEVV3iI A more vicious form of #COVID19 already created. Let's hope this one doesn't escape. It circumvents your immune system. #World
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @masahirono: 査読前論文であるが、回復者血清の存在下でSARS-CoV-2を培養すると、ウイルスは変異を徐々に獲得、80日目までに3箇所の変異(1箇所は11aa挿入)を含むようになり、その回復者血清に耐性になった(中和できなくなった)。同時に複数の回復者血清・…
@RiochtConor2 It's about to get a whole lot more complex. https://t.co/cgZEawhhCQ See how the E484k happens in lab experiments, reducing existing antibody response. Now note the next mutation that arises. This is still to be observed in humans, but E484k o
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
RT @masahirono: 査読前論文であるが、回復者血清の存在下でSARS-CoV-2を培養すると、ウイルスは変異を徐々に獲得、80日目までに3箇所の変異(1箇所は11aa挿入)を含むようになり、その回復者血清に耐性になった(中和できなくなった)。同時に複数の回復者血清・…
【変異種の根源】 まさかと思うがこれが変異種発生の根源なのだとしたら現在効果あると言われるワクチンなんて結局無効化されてしまう。 #新型コロナウイルス #武漢ウイルス #ワクチン #変異種 #変異株 https://t.co/ieqR2515Ep
Immune evasion is a thing. Covid19 variants show immune evasion both to immune response from natural infection and vaccination. https://t.co/eljI2fNqO7 https://t.co/uvYc1sedfR https://t.co/OGBYbOQK1e https://t.co/pochYwV4BZ https://t.co/ISaNzA1oPS https:/
@OffGuardian0 Apparently you can buy the virus: "Wild-type SARS CoV-2 2019 (2019-nCoV strain 2019-nCov/Italy-INMI1) virus was purchased from the European Virus Archive goes Global (EVAg, Spallanzani Institute, Rome)." https://t.co/dHgC47Q9dq
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
RT @hiima05415918: E484K置換について https://t.co/s9X0OB9sGv https://t.co/wN5pyYs5xe
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
#変異株 E484K には再感染やワクチン有効性低下の恐れがあります。 ● 回復期血漿と共培養した研究(プレプリント) https://t.co/nsEnC0ugro ● SARS-CoV-2; 再感染; E484K(プレプリント) https://t.co/NTiyAdtFJK https://t.co/qqwF6AUXeb
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
E484K置換について https://t.co/s9X0OB9sGv https://t.co/wN5pyYs5xe
RT @BillHanage: The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also…
The report also states that 11 genome sequences were obtained in which B.1.1.7 has acquired E484K, a mutation that is also found in the other variants and has been implicated in reduced neutralization by convalescent plasma 6/n https://t.co/LUM08azXsK
E484の突然変異の重要性が解る論文 [プレプリント] SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/9v584dGduD
RT @hussmanjp: @DrEricDing @nextstrain Oy. "At day 73, E484K substitution occurred, followed at day 80 by insertion to NTD N5 loop which ge…
😬
RT @hussmanjp: @DrEricDing @nextstrain Oy. "At day 73, E484K substitution occurred, followed at day 80 by insertion to NTD N5 loop which ge…
@DrEricDing @nextstrain Oy. "At day 73, E484K substitution occurred, followed at day 80 by insertion to NTD N5 loop which generated a variant completely resistant to plasma neutralization. Computational modeling predicts deletion/insertion in loops N3/N5 p
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/vT9Vhj0RMu Appears vaccine development responsible for new mutant English, South African and Brazil strains
@OYCar You say inevitably but are the next insertions from this experiment inevitable https://t.co/cgZEawhhCQ (I know it's not your background, but maybe you know someone)
RT @jbloom_lab: Heterogeneity also shown by @e_andreano @RommieAmaro @McLellan_Lab, who found multiple mutations that greatly (300-fold) re…
RT @jbloom_lab: These results broadly consistent w other studies that selected RBD mutations that greatly reduce neut by polyclonal sera. S…
RT @ncholiA: 3/ This was done using so-called passages. So this experiment was repeated over and over and after a whole number of repetitio…
RT @Williams_T_C: and outline how lab studies also show that the limited polyclonal response to Spike appears to also render the human hum…
@aykutuz Hatta bağışıklık sistemi zayıf olduğu için #coronavirus antikor oluşumu olmayan/geciken #COVID19 hastasında, bu olgu bizzat vücut içinde gözlemlenmiş. Bu nedenle özellikler G.Afrika'da HIV/AIDS hastaları yakın takipte. https://t.co/zlXV4XtEns
RT @jbloom_lab: Heterogeneity also shown by @e_andreano @RommieAmaro @McLellan_Lab, who found multiple mutations that greatly (300-fold) re…
RT @jbloom_lab: These results broadly consistent w other studies that selected RBD mutations that greatly reduce neut by polyclonal sera. S…
RT @Williams_T_C: and outline how lab studies also show that the limited polyclonal response to Spike appears to also render the human hum…
and outline how lab studies also show that the limited polyclonal response to Spike appears to also render the human humoral immune response vulnerable to viral genetic variability https://t.co/JWor2s395p 11/n https://t.co/8RzOQ1kP8Y
@NickytaLeb Pour les publis sur sérum de convalescent : https://t.co/e0EB0DdOqf https://t.co/Wv1boAwji1 https://t.co/0n1Qft3HVO
For examples of the situations mentioned in tweet 8, see for instance https://t.co/ckmy4MhTQ5, https://t.co/Ki9G6Az2i1 and https://t.co/Kz3oELADBR
RT @RajeevJayadevan: SARS-CoV2 virus can mutate at will to escape immunity. This important paper shows how just 3 mutations (causing rear…
@PZ_Nachrichten @WHO /2 Bei zeitgl. Infektion u. nicht ausreichender Clearance kann es aber zur Bildung von Mutationen kommen. Real in vitro nachgewiesen von Emanuele Andreano, et al.: https://t.co/zmBcmJFlBB (peer steht noch aus)
Amazing! #SARSCoV2 hoping our understanding of #viruses #immunology #pandemic leads to better control #Covid_19 #sciencematters @sciam @nature @ICMRDELHI @NCDCgov @GKangInd @UniofOxford #vaccine #PublicHealth #antivirals
RT @RajeevJayadevan: SARS-CoV2 virus can mutate at will to escape immunity. This important paper shows how just 3 mutations (causing rear…
SARS-CoV2 virus can mutate at will to escape immunity. This important paper shows how just 3 mutations (causing rearrangement of NTD N3 and N5 loops & one in RBD) eliminated the neutralization ability of a potent polyclonal serum. 1/2 https://t.co
@macroliter @laurenthehough Sadly it is hard to share your conviction. Here are two articles that illustrate why. This first one touches on research done AFTER Covid started travelling. https://t.co/jSv4Pleyti
@antonellaviol17 Questa pubblicazione di Rino Rappuoli (Fondazione Toscana Life Sciences, Siena) et al. potrebbe essere interessante: "SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma." https://t.co/f8ezfDxS4s
@virological_org All the insertions described in text arose after cell passage (lab manipulation). You haven´t mention Andreano et al. where an insertion of various aminoacids occurs in NTD after passages in presence of plasma of convalescent patient (KTRN
@NACREspirale @biorxivpreprint je ne crois pas un mot de ce que disent les gens de pfizer et de moderna... d'ailleurs les autres que j'ai moi meme indiqué non plus... https://t.co/4nD0ITZs8j
@aroradrn @EricTopol my2ct: German STIKO hypothetized "AB escacape" by prolonging the interval. But this AB escacape maybe could lead to mutations. (Limitations: Single in vitro model of stepwise selection) Emanuele Andreano, et al.: https://t.co/dpW9WTr53
RT @derpsmith: @ESYudkowsky You mean like this? https://t.co/z5XUtzYMws
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
Escape mutants on the horizon. https://t.co/SNWyXGuRt4
RT @MarkQuarter: SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma [12-2020. Monoclonal Antibody Discovery…
RT @MarkQuarter: " plasma fully neutralized virus for 7 passages but after 45 days, deletion of F140 in spike N-terminal domain (NTD) N3 lo…
#SARSCoV2 escape in vitro from a highly neutralizing #COVID19 convalescent plasma https://t.co/imT71mtZZ8
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
RT @StephaneKM: @Fabrice_Pilorge @sly1818 @SimoninCatheryn @HAS_sante Voici l'étude qui inquiète si fortement SAGE et les immuno (dont Akik…
@Fabrice_Pilorge @sly1818 @SimoninCatheryn @HAS_sante Voici l'étude qui inquiète si fortement SAGE et les immuno (dont Akiko Iwasaki qui était favorable à J42 jusque-là). Un trop faible taux d'Ac TRÈS neutralisants entraîne l'apparition de variants résista
RT @masan2014: これは怖い。ワクチン接種が世界各地で始まったのは良いことですが、これに耐性を持つ新たな変異ウイルスが登場することも危惧されています。 https://t.co/xR0Du5KHcF
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
@MinervaMcGrani1 @BidoliNicola @DReqvenge2020
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
Thinking about it, this is so gross. Are we sure this is not a hoax? Authors listed as GSK. This is really too strange.
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
3. From the paper.. "Three mutations allowed SARS-CoV-2 to evade the polyclonal antibody response of a highly neutralizing COVID-19 convalescent plasma." https://t.co/DYSfJayKP5
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma | bioRxiv @MackayIM 🥴🤷🏼♀️ is this a real experiment and if so it don’t seem to good? https://t.co/Ub7VnshGqf
@ESYudkowsky You mean like this? https://t.co/z5XUtzYMws
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
Wow! On est pas sorti de l'auberge avec les variants ... y compris chez les vaccinés ............ 🤔🤔🤔🤔🤔
New virus is made https://t.co/lcY7H6dKpt
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
RT @Pinzie: An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal im…
An important question for vaccine development is whether the authentic virus, under the selective pressure of the polyclonal immune response in convalescent or vaccinated people, can evolve to escape herd immunity and antibody treatment. https://t.co/KZ3YL
@ARanganathan72 ye kya locha hai? Please explain. https://t.co/DO0XvUkHvA
"The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants shoul
RT @ydeigin: Here’s the preprint: https://t.co/BrBRfjTOWU
Here’s the preprint: https://t.co/BrBRfjTOWU
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma https://t.co/hIgVPO5v4X