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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
|
|---|---|
| Published in |
Nature Communications, July 2016
|
| DOI | 10.1038/ncomms12180 |
| Pubmed ID | |
| Authors |
Hagoon Jang, Gha Young Lee, Christopher P. Selby, Gung Lee, Yong Geun Jeon, Jae Ho Lee, Kenneth King Yip Cheng, Paul Titchenell, Morris J. Birnbaum, Aimin Xu, Aziz Sancar, Jae Bum Kim |
| Abstract |
SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thoroughly understood. Here we show that CRY1 is activated by insulin-induced SREBP1c and decreases hepatic gluconeogenesis through FOXO1 degradation, at least, at specific circadian time points. SREBP1c(-/-) and CRY1(-/-) mice show higher blood glucose than wild-type (WT) mice in pyruvate tolerance tests, accompanied with enhanced expression of PEPCK and G6Pase genes. CRY1 promotes degradation of nuclear FOXO1 by promoting its binding to the ubiquitin E3 ligase MDM2. Although SREBP1c fails to upregulate CRY1 expression in db/db mice, overexpression of CRY1 attenuates hyperglycaemia through reduction of hepatic FOXO1 protein and gluconeogenic gene expression. These data suggest that insulin-activated SREBP1c downregulates gluconeogenesis through CRY1-mediated FOXO1 degradation and that dysregulation of hepatic SREBP1c-CRY1 signalling may contribute to hyperglycaemia in diabetic animals. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Japan | 2 | 33% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 96 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 22% |
| Student > Bachelor | 14 | 14% |
| Student > Master | 13 | 13% |
| Researcher | 11 | 11% |
| Professor | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 37% |
| Agricultural and Biological Sciences | 17 | 17% |
| Medicine and Dentistry | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Neuroscience | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2019.
All research outputs
#5,905,733
of 22,880,691 outputs
Outputs from Nature Communications
#33,673
of 47,132 outputs
Outputs of similar age
#98,351
of 355,133 outputs
Outputs of similar age from Nature Communications
#561
of 824 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 47,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 824 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.