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Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Overview of attention for article published in Gut, January 2021
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 6,738)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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Title
Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19
Published in
Gut, January 2021
DOI 10.1136/gutjnl-2020-323020
Pubmed ID
Authors

Yun Kit Yeoh, Tao Zuo, Grace Chung-Yan Lui, Fen Zhang, Qin Liu, Amy YL Li, Arthur CK Chung, Chun Pan Cheung, Eugene YK Tso, Kitty SC Fung, Veronica Chan, Lowell Ling, Gavin Joynt, David Shu-Cheong Hui, Kai Ming Chow, Susanna So Shan Ng, Timothy Chun-Man Li, Rita WY Ng, Terry CF Yip, Grace Lai-Hung Wong, Francis KL Chan, Chun Kwok Wong, Paul KS Chan, Siew C Ng

Abstract

Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus. In this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers were measured from plasma. Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals irrespective of whether patients had received medication (p<0.01). Several gut commensals with known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria were underrepresented in patients and remained low in samples collected up to 30 days after disease resolution. Moreover, this perturbed composition exhibited stratification with disease severity concordant with elevated concentrations of inflammatory cytokines and blood markers such as C reactive protein, lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyl transferase. Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19.

Twitter Demographics

The data shown below were collected from the profiles of 2,171 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 746 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 746 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 114 15%
Student > Bachelor 78 10%
Student > Master 76 10%
Student > Ph. D. Student 61 8%
Other 49 7%
Other 125 17%
Unknown 243 33%
Readers by discipline Count As %
Medicine and Dentistry 115 15%
Biochemistry, Genetics and Molecular Biology 108 14%
Immunology and Microbiology 71 10%
Agricultural and Biological Sciences 48 6%
Nursing and Health Professions 34 5%
Other 106 14%
Unknown 264 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 2443. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2022.
All research outputs
#2,569
of 22,106,685 outputs
Outputs from Gut
#1
of 6,738 outputs
Outputs of similar age
#189
of 490,592 outputs
Outputs of similar age from Gut
#1
of 62 outputs
Altmetric has tracked 22,106,685 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,738 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 490,592 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.