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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0046689 |
| Pubmed ID | |
| Authors |
Sang-Hyug Park, Woo Young Sim, Byoung-Hyun Min, Sang Sik Yang, Ali Khademhosseini, David L. Kaplan |
| Abstract |
Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs under dynamic hydraulic compression to evaluate and compare osteogenic abilities. A novel micro cell chip integrated with microvalves and microscale cell culture chambers separated from an air-pressure chamber was developed using microfabrication technology. The microscale chip enables the culture of two types of stem cells concurrently, where each is loaded into cell culture chambers and dynamic compressive stimulation is applied to the cells uniformly. Dynamic hydraulic compression (1 Hz, 1 psi) increased the production of osteogenic matrix components (bone sialoprotein, oateopontin, type I collagen) and integrin (CD11b and CD31) expression from both stem cell sources. Alkaline phosphatase and Alrizarin red staining were evident in the stimulated hMSCs, while the stimulated hASCs did not show significant increases in staining under the same stimulation conditions. Upon application of mechanical stimulus to the two types of stem cells, integrin (β1) and osteogenic gene markers were upregulated from both cell types. In conclusion, stimulated hMSCs and hASCs showed increased osteogenic gene expression compared to non-stimulated groups. The hMSCs were more sensitive to mechanical stimulation and more effective towards osteogenic differentiation than the hASCs under these modes of mechanical stimulation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 1% |
| Germany | 1 | <1% |
| Turkey | 1 | <1% |
| Sweden | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 185 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 27% |
| Researcher | 31 | 16% |
| Student > Master | 21 | 11% |
| Student > Bachelor | 15 | 8% |
| Student > Doctoral Student | 10 | 5% |
| Other | 32 | 17% |
| Unknown | 31 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 42 | 22% |
| Agricultural and Biological Sciences | 30 | 16% |
| Biochemistry, Genetics and Molecular Biology | 29 | 15% |
| Medicine and Dentistry | 16 | 8% |
| Materials Science | 10 | 5% |
| Other | 22 | 12% |
| Unknown | 42 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2021.
All research outputs
#13,925,649
of 22,774,233 outputs
Outputs from PLOS ONE
#112,337
of 194,339 outputs
Outputs of similar age
#97,373
of 172,272 outputs
Outputs of similar age from PLOS ONE
#2,344
of 4,427 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,339 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,272 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,427 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.