Title |
Calcium homeostasis in aging neurons
|
---|---|
Published in |
Frontiers in Genetics, January 2012
|
DOI | 10.3389/fgene.2012.00200 |
Pubmed ID | |
Authors |
Vassiliki Nikoletopoulou, Nektarios Tavernarakis |
Abstract |
The nervous system becomes increasingly vulnerable to insults and prone to dysfunction during aging. Age-related decline of neuronal function is manifested by the late onset of many neurodegenerative disorders, as well as by reduced signaling and processing capacity of individual neuron populations. Recent findings indicate that impairment of Ca(2+) homeostasis underlies the increased susceptibility of neurons to damage, associated with the aging process. However, the impact of aging on Ca(2+) homeostasis in neurons remains largely unknown. Here, we survey the molecular mechanisms that mediate neuronal Ca(2+) homeostasis and discuss the impact of aging on their efficacy. To address the question of how aging impinges on Ca(2+) homeostasis, we consider potential nodes through which mechanisms regulating Ca(2+) levels interface with molecular pathways known to influence the process of aging and senescent decline. Delineation of this crosstalk would facilitate the development of interventions aiming to fortify neurons against age-associated functional deterioration and death by augmenting Ca(2+) homeostasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
Germany | 2 | 1% |
United States | 2 | 1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 158 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 25% |
Student > Master | 27 | 16% |
Student > Bachelor | 18 | 11% |
Researcher | 13 | 8% |
Student > Doctoral Student | 9 | 5% |
Other | 23 | 14% |
Unknown | 35 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 21% |
Neuroscience | 34 | 20% |
Biochemistry, Genetics and Molecular Biology | 29 | 17% |
Medicine and Dentistry | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 11 | 7% |
Unknown | 41 | 25% |