1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages

1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages https://t.co/YXCqFlHmsl

#septicemia #septicaemia #pediatrics Significantly higher HMGB1 in children with Down syndrome https://t.co/HQmrBJuNhZ . The toxic gut microbiota metabolite LPS increases HMGB1 (a risk factor for sepsis). . Adequate vitamin D from sunlight reduces HMGB1

#microbiome #sepsis #inflammation The toxic gut microbiota metabolite LPS increases HMGB1 (a risk factor for sepsis). Adequate vitamin D from sunlight reduces HMGB1. . https://t.co/OtLGb8CE9e

Importantly, Vit D or 1,25-Dihydroxyvitamin D specifically inhibits the extracellular release of HMGB1 by activating Nrf2 and inducing the expression of HO-1, which is essential for blocking HMBG1 nuclear translocation and its secretion. https://t.co/M6jaB