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Confocal Laser Scanning Microscopy Evaluation of an Acellular Dermis Tissue Transplant (Epiflex®)

Overview of attention for article published in PLOS ONE, October 2012
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2 X users

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Title
Confocal Laser Scanning Microscopy Evaluation of an Acellular Dermis Tissue Transplant (Epiflex®)
Published in
PLOS ONE, October 2012
DOI 10.1371/journal.pone.0045991
Pubmed ID
Authors

Eric Dominic Roessner, Mario Vitacolonna, Peter Hohenberger

Abstract

The structure of a biological scaffold is a major determinant of its biological characteristics and its interaction with cells. An acellular dermis tissue transplant must undergo a series of processing steps, to remove cells and genetic material and provide the sterility required for surgical use. During manufacturing and sterilization the structure and composition of tissue transplants may change. The composition of the human cell-free dermis transplant Epiflex® was investigated with specific attention paid to its structure, matrix composition, cellular content and biomechanics. We demonstrated that after processing, the structure of Epiflex remains almost unchanged with an intact collagen network and extracellular matrix (ECM) protein composition providing natural cell interactions. Although the ready to use transplant does contain some cellular and DNA debris, the processing procedure results in a total destruction of cells and active DNA which is a requirement for an immunologically inert and biologically safe substrate. Its biomechanical parameters do not change significantly during the processing.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Germany 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 38%
Student > Ph. D. Student 3 12%
Other 2 8%
Student > Bachelor 2 8%
Student > Master 2 8%
Other 2 8%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 42%
Medicine and Dentistry 4 15%
Neuroscience 1 4%
Chemistry 1 4%
Materials Science 1 4%
Other 1 4%
Unknown 7 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2013.
All research outputs
#14,734,103
of 22,679,690 outputs
Outputs from PLOS ONE
#122,922
of 193,573 outputs
Outputs of similar age
#104,548
of 172,325 outputs
Outputs of similar age from PLOS ONE
#2,682
of 4,541 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,573 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,325 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,541 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.