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Association of the Maternal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects in Offsprings: Evidence from 25 Case-Control Studies

Overview of attention for article published in PLOS ONE, October 2012
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Citations

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Title
Association of the Maternal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects in Offsprings: Evidence from 25 Case-Control Studies
Published in
PLOS ONE, October 2012
DOI 10.1371/journal.pone.0041689
Pubmed ID
Authors

Lifeng Yan, Lin Zhao, Yan Long, Peng Zou, Guixiang Ji, Aihua Gu, Peng Zhao

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA methylation, DNA synthesis, and DNA repair. In addition, it is a possible risk factor in neural tube defects (NTDs). The association of the C677T polymorphism in the MTHFR gene and NTD susceptibility has been widely demonstrated, but the results remain inconclusive. In this study, we performed a meta-analysis with 2429 cases and 3570 controls to investigate the effect of the MTHFR C677T polymorphism on NTDs.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Unknown 113 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 33 29%
Student > Master 22 19%
Student > Postgraduate 8 7%
Student > Ph. D. Student 8 7%
Student > Doctoral Student 7 6%
Other 23 20%
Unknown 13 11%
Readers by discipline Count As %
Medicine and Dentistry 32 28%
Biochemistry, Genetics and Molecular Biology 21 18%
Agricultural and Biological Sciences 20 18%
Nursing and Health Professions 8 7%
Neuroscience 5 4%
Other 11 10%
Unknown 17 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2022.
All research outputs
#1,128,230
of 25,827,956 outputs
Outputs from PLOS ONE
#14,363
of 225,158 outputs
Outputs of similar age
#6,520
of 192,372 outputs
Outputs of similar age from PLOS ONE
#222
of 4,537 outputs
Altmetric has tracked 25,827,956 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 225,158 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,372 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4,537 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.