↓ Skip to main content

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

Overview of attention for article published in Genome Biology (Online Edition), January 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
5 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
111 Dimensions

Readers on

mendeley
160 Mendeley
citeulike
3 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions
Published in
Genome Biology (Online Edition), January 2012
DOI 10.1186/gb-2012-13-10-r85
Pubmed ID
Authors

Manching Ku, Jacob D Jaffe, Richard P Koche, Esther Rheinbay, Mitsuhiro Endoh, Haruhiko Koseki, Steven A Carr, Bradley E Bernstein

Abstract

ABSTRACT: BACKGROUND: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. RESULTS: We mapped H2A.Z genome-wide in mammalian ES cells and neural progenitors. H2A.Z is deposited promiscuously at promoters and enhancers, and correlates strongly with H3K4 methylation. Accordingly, H2A.Z is present at poised promoters with bivalent chromatin and at active promoters with H3K4 methylation, but is absent from stably repressed promoters that are specifically enriched for H3K27 trimethylation. We also characterized post-translational modification states of H2A.Z, including a novel species dually-modified by ubiquitination and acetylation that is enriched at bivalent chromatin. CONCLUSIONS: Our findings associate H2A.Z with functionally distinct genomic elements, and suggest that post-translational modifications may reconcile its contrasting locations and roles.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 3%
United Kingdom 2 1%
Austria 1 <1%
Korea, Republic of 1 <1%
Italy 1 <1%
France 1 <1%
Sweden 1 <1%
Netherlands 1 <1%
Canada 1 <1%
Other 2 1%
Unknown 144 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 38%
Researcher 39 24%
Student > Master 15 9%
Professor > Associate Professor 10 6%
Student > Bachelor 8 5%
Other 24 15%
Unknown 3 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 101 63%
Biochemistry, Genetics and Molecular Biology 36 23%
Medicine and Dentistry 6 4%
Neuroscience 4 3%
Chemistry 3 2%
Other 7 4%
Unknown 3 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2016.
All research outputs
#1,121,883
of 8,836,968 outputs
Outputs from Genome Biology (Online Edition)
#1,167
of 2,447 outputs
Outputs of similar age
#12,816
of 104,521 outputs
Outputs of similar age from Genome Biology (Online Edition)
#36
of 60 outputs
Altmetric has tracked 8,836,968 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,447 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.