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Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex

Overview of attention for article published in PLOS ONE, October 2012
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Title
Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex
Published in
PLOS ONE, October 2012
DOI 10.1371/journal.pone.0047574
Pubmed ID
Authors

Ying-Zu Huang, Chin-Song Lu, John C. Rothwell, Chung-Chuan Lo, Wen-Li Chuang, Yi-Hsin Weng, Szu-Chia Lai, Rou-Shayn Chen

Abstract

Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention. Here we show in patients with focal hand dystonia that additional, new effects build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. In a sham-controlled study, real or sham continuous theta burst stimulation (cTBS) was given once daily for five consecutive days to dorsolateral premotor cortex (PMd). Five days of real, but not sham, premotor cTBS improved intracortical inhibition in primary motor cortex (M1) to a similar extent on day 1 and day 5. However 5 days of cTBS were required to restore the abnormal PMd-M1 interactions observed on day 1. Similarly, excessive M1 plasticity seen at baseline was also significantly reduced by five days of real premotor cTBS. There was only a marginal benefit on writing. The results show that additional, new effects, at sites distant from the point of stimulation, build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. The results indicate that it may take many days of therapeutic intervention to rebalance activity in a complex network.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
France 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 36%
Student > Master 4 9%
Professor 4 9%
Student > Bachelor 3 7%
Researcher 3 7%
Other 7 16%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Neuroscience 9 20%
Psychology 5 11%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 2 5%
Other 6 14%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2012.
All research outputs
#13,369,262
of 22,681,577 outputs
Outputs from PLOS ONE
#106,427
of 193,576 outputs
Outputs of similar age
#93,161
of 172,656 outputs
Outputs of similar age from PLOS ONE
#2,236
of 4,570 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,576 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,656 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,570 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.