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Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells

Overview of attention for article published in BMC Biotechnology, January 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

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23 Dimensions

Readers on

mendeley
37 Mendeley
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Title
Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
Published in
BMC Biotechnology, January 2012
DOI 10.1186/1472-6750-12-72
Pubmed ID
Authors

Yasuhiko Sumitomo, Hiroaki Higashitsuji, Hisako Higashitsuji, Yu Liu, Takanori Fujita, Toshiharu Sakurai, Marco M Candeias, Katsuhiko Itoh, Tsutomu Chiba, Jun Fujita

Abstract

There are a growing number of reports on the sub-physiological temperature culturing of mammalian cells for increased recombinant protein yields. However, the effect varies and the reasons for the enhancement are not fully elucidated. Expression of cold-inducible RNA-binding protein (cirp, also called cirbp or hnRNP A18) is known to be induced in response to mild, but not severe, hypothermia in mammalian cells. To clarify the molecular mechanism underlying the induction and to exploit this to improve the productivity of recombinant proteins, we tried to identify the regulatory sequence(s) in the 5' flanking region of the mouse cirp gene.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 35%
Student > Doctoral Student 7 19%
Researcher 6 16%
Other 3 8%
Student > Master 2 5%
Other 4 11%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 43%
Biochemistry, Genetics and Molecular Biology 12 32%
Medicine and Dentistry 3 8%
Chemical Engineering 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2018.
All research outputs
#3,932,661
of 14,854,534 outputs
Outputs from BMC Biotechnology
#261
of 787 outputs
Outputs of similar age
#32,680
of 134,536 outputs
Outputs of similar age from BMC Biotechnology
#1
of 1 outputs
Altmetric has tracked 14,854,534 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 787 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them