Title |
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial
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Published in |
BMC Psychiatry, October 2012
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DOI | 10.1186/1471-244x-12-167 |
Pubmed ID | |
Authors |
Elizabeth V Cyarto, Nicola T Lautenschlager, Patricia M Desmond, David Ames, Cassandra Szoeke, Olivier Salvado, Matthew J Sharman, Kathryn A Ellis, Pramit M Phal, Colin L Masters, Christopher C Rowe, Ralph N Martins, Kay L Cox |
Abstract |
Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these benefits in high-risk populations. The aim of AIBL Active is to determine whether a 24-month physical activity program can delay the progression of white matter changes on magnetic resonance imaging (MRI). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Egypt | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
Netherlands | 1 | <1% |
Ireland | 1 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 465 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 72 | 15% |
Student > Ph. D. Student | 69 | 15% |
Student > Bachelor | 59 | 12% |
Researcher | 52 | 11% |
Student > Doctoral Student | 23 | 5% |
Other | 77 | 16% |
Unknown | 121 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 82 | 17% |
Psychology | 73 | 15% |
Nursing and Health Professions | 46 | 10% |
Neuroscience | 32 | 7% |
Sports and Recreations | 24 | 5% |
Other | 70 | 15% |
Unknown | 146 | 31% |