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A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia

Overview of attention for article published in PLOS ONE, October 2012
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Title
A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia
Published in
PLOS ONE, October 2012
DOI 10.1371/journal.pone.0047055
Pubmed ID
Authors

Nisreen Kweider, Berthold Huppertz, Christoph Jan Wruck, Rainer Beckmann, Werner Rath, Thomas Pufe, Mamed Kadyrov

Abstract

Preeclampsia (PE) is characterized by increased lipid oxidation and diminished antioxidant capacity, while intrauterine growth restriction (IUGR) is characterized by impaired invasion of the extravillous trophoblast. Vascular endothelial growth factor (VEGF) has been reported to be altered in preeclampsia. A relationship between VEGF and nuclear factor erythroid 2-related factor-2 (Nrf2) has been shown in vitro, where VEGF prevents oxidative damage via activation of the Nrf2 pathway. In this study the expression of Nrf2, VEGF and 4-hydroxynonenal (4-HNE), was determined in interstitial and endovascular/intramural extravillous trophoblast (EVT) in normal pregnancies and those complicated by severe early onset IUGR associated with preeclampsia IUGR/PE.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Canada 1 1%
Egypt 1 1%
Unknown 64 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 19%
Student > Ph. D. Student 11 16%
Student > Master 9 13%
Researcher 9 13%
Professor > Associate Professor 4 6%
Other 9 13%
Unknown 13 19%
Readers by discipline Count As %
Medicine and Dentistry 18 26%
Agricultural and Biological Sciences 12 18%
Biochemistry, Genetics and Molecular Biology 11 16%
Nursing and Health Professions 3 4%
Sports and Recreations 2 3%
Other 7 10%
Unknown 15 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2019.
All research outputs
#15,708,439
of 23,342,092 outputs
Outputs from PLOS ONE
#135,683
of 199,597 outputs
Outputs of similar age
#109,669
of 174,073 outputs
Outputs of similar age from PLOS ONE
#2,854
of 4,572 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 199,597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,073 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,572 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.