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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Natural and man-made V-gene repertoires for antibody discovery
|
|---|---|
| Published in |
Frontiers in immunology, January 2012
|
| DOI | 10.3389/fimmu.2012.00342 |
| Pubmed ID | |
| Authors |
William J. J. Finlay, Juan C. Almagro |
| Abstract |
Antibodies are the fastest-growing segment of the biologics market. The success of antibody-based drugs resides in their exquisite specificity, high potency, stability, solubility, safety, and relatively inexpensive manufacturing process in comparison with other biologics. We outline here the structural studies and fundamental principles that define how antibodies interact with diverse targets. We also describe the antibody repertoires and affinity maturation mechanisms of humans, mice, and chickens, plus the use of novel single-domain antibodies in camelids and sharks. These species all utilize diverse evolutionary solutions to generate specific and high affinity antibodies and illustrate the plasticity of natural antibody repertoires. In addition, we discuss the multiple variations of man-made antibody repertoires designed and validated in the last two decades, which have served as tools to explore how the size, diversity, and composition of a repertoire impact the antibody discovery process. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Ireland | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 48 | 32% |
| Student > Ph. D. Student | 31 | 21% |
| Student > Master | 13 | 9% |
| Other | 10 | 7% |
| Student > Bachelor | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 18 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 41% |
| Biochemistry, Genetics and Molecular Biology | 28 | 19% |
| Immunology and Microbiology | 17 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Engineering | 4 | 3% |
| Other | 13 | 9% |
| Unknown | 20 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#7,778,071
of 25,371,288 outputs
Outputs from Frontiers in immunology
#9,043
of 31,513 outputs
Outputs of similar age
#65,597
of 250,087 outputs
Outputs of similar age from Frontiers in immunology
#49
of 275 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 31,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.