Title |
Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview
|
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Published in |
Frontiers in immunology, May 2017
|
DOI | 10.3389/fimmu.2017.00548 |
Pubmed ID | |
Authors |
Claire Immediato Daïen, Gabriela Veronica Pinget, Jian Kai Tan, Laurence Macia |
Abstract |
Dietary fibers are non-digestible polysaccharides functionally known as microbiota-accessible carbohydrates (MACs), present in inadequate amounts in the Western diet. MACs are a main source of energy for gut bacteria so the abundance and variety of MACs can modulate gut microbial composition and function. This, in turn, impacts host immunity and health. In preclinical studies, MAC-deprived diet and disruption of gut homeostasis aggravate the development of inflammatory diseases, such as allergies, infections, and autoimmune diseases. The present review provides a synopsis on the impact of a low-MAC diet on gut homeostasis or, more specifically, on gut microbiota, gut epithelium, and immune cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 12% |
Spain | 14 | 11% |
United Kingdom | 10 | 8% |
Canada | 7 | 6% |
Mexico | 5 | 4% |
India | 5 | 4% |
Switzerland | 2 | 2% |
Ecuador | 2 | 2% |
Netherlands | 2 | 2% |
Other | 11 | 9% |
Unknown | 52 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 83 | 66% |
Practitioners (doctors, other healthcare professionals) | 23 | 18% |
Scientists | 17 | 14% |
Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 187 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 19% |
Student > Master | 22 | 12% |
Student > Ph. D. Student | 20 | 11% |
Student > Bachelor | 20 | 11% |
Other | 13 | 7% |
Other | 32 | 17% |
Unknown | 44 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 16% |
Biochemistry, Genetics and Molecular Biology | 22 | 12% |
Agricultural and Biological Sciences | 21 | 11% |
Immunology and Microbiology | 17 | 9% |
Nursing and Health Professions | 15 | 8% |
Other | 28 | 15% |
Unknown | 54 | 29% |