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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity
|
|---|---|
| Published in |
Frontiers in Microbiology, May 2016
|
| DOI | 10.3389/fmicb.2016.00622 |
| Pubmed ID | |
| Authors |
Ewa Otręebska-Machaj, Jacqueline Chevalier, Jadwiga Handzlik, Ewa Szymańska, Jakub Schabikowski, Gérard Boyer, Jean-Michel Bolla, Katarzyna Kieć-Kononowicz, Jean-Marie Pagès, Sandrine Alibert |
| Abstract |
Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically important antibiotic classes out of the cell. Drug pumps are attractive targets to restore the susceptibility toward the expelled antibiotics by impairing their efflux activity. Arylhydantoin derivatives were investigated for their potentiation of activities of selected antibiotics described as efflux substrates in Enterobacter aerogenes expressing or not AcrAB pump. Several compounds increased the bacterial susceptibility toward nalidixic acid, chloramphenicol and sparfloxacin and were further pharmacomodulated to obtain a better activity against the AcrAB producing bacteria. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 21% |
| Student > Ph. D. Student | 8 | 17% |
| Researcher | 6 | 13% |
| Student > Doctoral Student | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 13 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 15% |
| Chemistry | 7 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Agricultural and Biological Sciences | 4 | 8% |
| Other | 6 | 13% |
| Unknown | 14 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2016.
All research outputs
#17,550,880
of 25,732,188 outputs
Outputs from Frontiers in Microbiology
#17,937
of 29,747 outputs
Outputs of similar age
#192,890
of 313,225 outputs
Outputs of similar age from Frontiers in Microbiology
#373
of 581 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 29,747 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,225 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 581 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.