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X Demographics
Mendeley readers
Attention Score in Context
| Title |
De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, November 2014
|
| DOI | 10.3389/fncel.2014.00373 |
| Pubmed ID | |
| Authors |
Roman M. Stilling, Eva Benito, Michael Gertig, Jonas Barth, Vincenzo Capece, Susanne Burkhardt, Stefan Bonn, Andre Fischer |
| Abstract |
Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer's disease (AD). The underlying mechanisms are however not well understood. Here we analyze the hippocampal transcriptome of young adult mice and two groups of mice at advanced age using RNA sequencing. This approach enabled us to test differential expression of coding and non-coding transcripts, as well as differential splicing and RNA editing. We report a specific age-associated gene expression signature that is associated with major genetic risk factors for late-onset AD (LOAD). This signature is dominated by neuroinflammatory processes, specifically activation of the complement system at the level of increased gene expression, while de-regulation of neuronal plasticity appears to be mediated by compromised RNA splicing. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 40% |
| Ireland | 2 | 20% |
| Switzerland | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Ireland | 1 | <1% |
| Czechia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Researcher | 24 | 16% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 10 | 7% |
| Other | 25 | 17% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 46 | 31% |
| Biochemistry, Genetics and Molecular Biology | 22 | 15% |
| Neuroscience | 22 | 15% |
| Medicine and Dentistry | 8 | 5% |
| Psychology | 5 | 3% |
| Other | 10 | 7% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2022.
All research outputs
#5,805,262
of 23,322,966 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,058
of 4,320 outputs
Outputs of similar age
#62,140
of 260,139 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#11
of 81 outputs
Altmetric has tracked 23,322,966 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,320 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,139 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.