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Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis

Overview of attention for article published in Frontiers in Pharmacology, May 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

peer_reviews
1 peer review site
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
86 Dimensions

Readers on

mendeley
98 Mendeley
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Title
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis
Published in
Frontiers in Pharmacology, May 2014
DOI 10.3389/fphar.2014.00104
Pubmed ID
Authors

Amanda B. Core, Susanna Canali, Jodie L. Babitt

Abstract

Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis. This review highlights recent work uncovering the mechanism of action of HJV and the BMP-SMAD signaling pathway in regulating hepcidin expression in the liver, as well as additional studies investigating possible extra-hepatic functions of HJV. This review also explores the interaction between HJV, the BMP-SMAD signaling pathway and other regulators of hepcidin expression in systemic iron balance.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Unknown 97 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 17%
Student > Bachelor 12 12%
Researcher 11 11%
Student > Postgraduate 8 8%
Student > Master 8 8%
Other 14 14%
Unknown 28 29%
Readers by discipline Count As %
Medicine and Dentistry 20 20%
Biochemistry, Genetics and Molecular Biology 19 19%
Agricultural and Biological Sciences 17 17%
Immunology and Microbiology 3 3%
Nursing and Health Professions 2 2%
Other 6 6%
Unknown 31 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2019.
All research outputs
#6,413,376
of 22,786,087 outputs
Outputs from Frontiers in Pharmacology
#2,628
of 16,015 outputs
Outputs of similar age
#61,518
of 226,981 outputs
Outputs of similar age from Frontiers in Pharmacology
#20
of 82 outputs
Altmetric has tracked 22,786,087 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 16,015 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.