Title |
Genomic sequencing for psychiatric disorders: promise and challenge
|
---|---|
Published in |
The International Journal of Neuropsychopharmacology, August 2013
|
DOI | 10.1017/s146114571300014x |
Pubmed ID | |
Authors |
Barbara Bowles Biesecker, Holly Landrum Peay |
Abstract |
Whole genome/exome sequencing (WGS/WES) integration into medicine will yield a new disease paradigm moving from clinical to molecular diagnosis. This paradigm will present significant challenges in the interpretation of sequence data and clinicians will face dilemmas about if, when and how to offer information to patients. Sequencing will ultimately reshape psychiatry in predicting disease risk and lead to greater understanding of aetiology, prognosis and/or treatment response. This commentary on the ethics of returning WGS/WES results describes the nature of the data as a dynamic health resource, the importance of understanding participant motivations, determinations of personal utility and potential effects of WGS/WES on self-concept and well-being. As this technology unfurls, ethical challenges will not be novel but they will be compounded by the volume and scope of the data. Research into participant/patient perceptions, preferences and outcomes will identify areas of caution and prepare psychiatrists for eventual integration into clinical care. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 13% |
Australia | 1 | 13% |
South Africa | 1 | 13% |
Canada | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 19% |
Researcher | 6 | 14% |
Other | 5 | 12% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 2 | 5% |
Other | 12 | 29% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 24% |
Agricultural and Biological Sciences | 8 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Psychology | 5 | 12% |
Neuroscience | 2 | 5% |
Other | 4 | 10% |
Unknown | 7 | 17% |