@matteoferla Issue is not how obtained. Increased ionization improves metrics like LLE if logD (rather than logP) is used but is likely to compromise permeability and unlikely to improve off-target (e.g. hERG) activity. See "Consider as a thought experime
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@katykellett1 @davidlmobley Hopefully they'll stop using metrics as well https://t.co/ajhwUaM31p
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@JenniferLoveUBC @dasingleton Glad you liked it and good luck skewering any metrics that should happen to stray into the cross-hairs. While I hate all metrics, I have a special distaste for #LigandEfficiency https://t.co/ajhwUaM31p
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@GTsodikova @MedChemComm Sometimes ( https://t.co/XOzjaAuFRp ) although blogging ( https://t.co/xcc42g7OJc) is much more fun