Title |
Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism
|
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Published in |
Current Environmental Health Reports, October 2017
|
DOI | 10.1007/s40572-017-0170-z |
Pubmed ID | |
Authors |
Carolyn McCabe, Olivia S. Anderson, Luke Montrose, Kari Neier, Dana C. Dolinoy |
Abstract |
The genetic material of every organism exists within the context of regulatory networks that govern gene expression-collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic programming and vulnerable to environmental insults. Thus, epigenetics represent a potential mechanism through which sexually dimorphic effects of early-life exposures such as endocrine-disrupting chemicals (EDCs) manifest. Several animal studies, and to a lesser extent human studies, have evaluated life-course sexually dimorphic health effects following developmental toxicant exposures; many fewer studies, however, have evaluated epigenetics as a mechanism mediating developmental exposures and later outcomes. To evaluate epigenetic reprogramming as a mechanistic link of sexually dimorphic early-life EDCs exposures, the following criteria should be met: (1) well-characterized exposure paradigm that includes relevant windows for developmental epigenetic reprogramming; (2) evaluation of sex-specific exposure-related epigenetic change; and (3) observation of a sexually dimorphic phenotype in either childhood, adolescence, or adulthood. |
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Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
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Unknown | 62 | 100% |
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Student > Bachelor | 9 | 15% |
Researcher | 9 | 15% |
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Student > Doctoral Student | 7 | 11% |
Other | 8 | 13% |
Unknown | 10 | 16% |
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Neuroscience | 4 | 6% |
Other | 7 | 11% |
Unknown | 17 | 27% |