Chapter title |
Immunomodulatory Role of Vitamin D: A Review
|
---|---|
Chapter number | 246 |
Book title |
Current Trends in Immunity and Respiratory Infections
|
Published in |
Advances in experimental medicine and biology, August 2018
|
DOI | 10.1007/5584_2018_246 |
Pubmed ID | |
Book ISBNs |
978-3-03-001634-0, 978-3-03-001635-7
|
Authors |
Skrobot, Agnieszka, Demkow, Urszula, Wachowska, Małgorzata, Agnieszka Skrobot, Urszula Demkow, Małgorzata Wachowska |
Abstract |
Vitamin D is well known for its classical hormonal action related to the maintenance of mineral and skeletal homeostasis. However, the discovery that vitamin D receptor (VDR) is expressed in most non-skeletal tissues points to its broad role in the human organism. Current literature emphasizes a multidirectional role of vitamin D, with a special focus on its immunomodulatory properties. As VDR and the enzyme 1-α-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells. In addition, it induces the microbicidal activity of phagocytes. In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells. In this review we aimed to describe the current scientific discoveries on the role of vitamin D as immunomodulator. |
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Mendeley readers
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Demographic breakdown
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Student > Ph. D. Student | 9 | 11% |
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Unknown | 41 | 52% |