Title |
Single dose oral dexamethasone versus multi-dose prednisolone in the treatment of acute exacerbations of asthma in children who attend the emergency department: study protocol for a randomized controlled trial
|
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Published in |
Trials, August 2012
|
DOI | 10.1186/1745-6215-13-141 |
Pubmed ID | |
Authors |
John Cronin, Una Kennedy, Siobhan McCoy, Sinéad Nic an Fhailí, Gloria Crispino-O’Connell, John Hayden, Abel Wakai, Sean Walsh, Ronan O’Sullivan |
Abstract |
Asthma is a major cause of pediatric morbidity and mortality. In acute exacerbations of asthma, corticosteroids reduce relapses, subsequent hospital admission and the need for ß₂-agonist therapy. Prednisolone is relatively short-acting with a half-life of 12 to 36 hours, thereby requiring daily dosing. Prolonged treatment course, vomiting and a bitter taste may reduce patient compliance with prednisolone. Dexamethasone is a long-acting corticosteroid with a half-life of 36 to 72 hours. It is used frequently in children with croup and bacterial meningitis, and is well absorbed orally. The purpose of this trial is to examine whether a single dose of oral dexamethasone (0.3 mg/kg) is clinically non-inferior to prednisolone (1 mg/kg/day for three days) in the treatment of exacerbations of asthma in children who attend the Emergency Department. |
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Country | Count | As % |
---|---|---|
United Kingdom | 2 | 29% |
United States | 1 | 14% |
Ireland | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
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Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 3% |
Peru | 1 | <1% |
Australia | 1 | <1% |
Unknown | 119 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 20 | 16% |
Student > Bachelor | 18 | 14% |
Researcher | 16 | 13% |
Student > Ph. D. Student | 12 | 10% |
Other | 10 | 8% |
Other | 27 | 22% |
Unknown | 22 | 18% |
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Medicine and Dentistry | 53 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 10% |
Nursing and Health Professions | 7 | 6% |
Agricultural and Biological Sciences | 6 | 5% |
Economics, Econometrics and Finance | 4 | 3% |
Other | 18 | 14% |
Unknown | 25 | 20% |