Title |
Detection and molecular characterization of β-lactamase genes in clinical isolates of Gram-negative bacteria in Southern Ecuador
|
---|---|
Published in |
Brazilian Journal of Infectious Diseases, July 2016
|
DOI | 10.1016/j.bjid.2016.07.001 |
Pubmed ID | |
Authors |
Diana Yessenia Calva Delgado, Zorayda Patricia Toledo Barrigas, Sofía Genoveva Ochoa Astutillo, Ana Paulina Arévalo Jaramillo, Alessio Ausili |
Abstract |
This work performed a phenotypic and genotypic characterization of 79 clinical isolates of Enterobacteriaceae and Pseudomonadaceae collected in hospitals of Southern Ecuadorin 2013. Our results showed a high incidence of β-lactamases and ESBLs with blaTEM and blaCTX-M as the prevalent genes, respectively. By direct sequencing of PCR amplicons, the different β-lactamases and variants of the genes were also distinguished. Our results revealed a predominance of TEM-1 β-lactamase and the presence of different CTX-M variants with a prevalence of CTX-M-15. Two infrequent CTX-M variants in South America were also identified. To the best of our knowledge, this is one of the first studies describing the genetic characteristics of β-lactamases in Ecuador. |
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Unknown | 1 | 100% |
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Mendeley readers
Geographical breakdown
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 15% |
Student > Master | 10 | 14% |
Researcher | 9 | 13% |
Student > Ph. D. Student | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 8 | 11% |
Unknown | 23 | 32% |
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Immunology and Microbiology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Medicine and Dentistry | 4 | 6% |
Other | 9 | 13% |
Unknown | 27 | 38% |