Carolyn A. de Graaf, Jarny Choi, Tracey M. Baldwin, Jessica E. Bolden, Kirsten A. Fairfax, Aaron J. Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P. Ng, Maria Kauppi, Elizabeth A. Kruse, Tobias J. Sargeant, Nick Seidenman, Angela D'Amico, Marthe C. D'Ombrain, Erin C. Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J. Wilson, Steven K. Dower, Brenda Williams, Shen Y. Heazlewood, Yifang Hu, Susan K. Nilsson, Li Wu, Gordon K. Smyth, Warren S. Alexander, Douglas J. Hilton
Abstract
Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2016.
All research outputs
#1,733,192
of 26,462,556 outputs
Outputs from Stem Cell Reports
#500
of 2,194 outputs
Outputs of similar age
#31,112
of 386,087 outputs
Outputs of similar age from Stem Cell Reports
#7
of 51 outputs
Altmetric has tracked 26,462,556 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,194 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.1. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.
