Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).

Rosa, Regis Goulart, Robinson, Caroline Cabral, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Azevedo, Luciano César Pontes de, Machado, Flávia Ribeiro, Berwanger, Otavio, Avezum, Álvaro, Lopes, Renato Delascio, Lisboa, Thiago Costa, Teixeira, Cassiano, Zampieri, Fernando Godinho, Tomazini, Bruno Martins, Kawano-Dourado, Letícia, Schneider, Daniel, Souza, Denise de, Santos, Rosa da Rosa Minho Dos, Silva, Sabrina Souza da, Trott, Geraldine, Gimenes, Bruna Dos Passos, Souza, Ana Paula de, Barroso, Bruna Machado, Costa, Lauren Sezerá, Brognoli, Liége Gregoletto, Pelliccioli, Melissa Pezzetti, Studier, Nicole Dos Santos, Schardosim, Raíne Fogliati de Carli, Haubert, Tainá Aparecida, Pallaoro, Victoria Emanuele Lobo, Oliveira, Debora Mariani de, Velho, Pedro Isaacsson, Medeiros, Gregory Saraiva, Gazzana, Marcelo Basso, Zavascki, Alexandre Prehn, Pitrez, Paulo Márcio, Oliveira, Roselaine Pinheiro de, Polanczyk, Carisi Anne, Nasi, Luiz Antônio, Hammes, Luciano Serpa, Falavigna, Maicon, Santos, Rosa da Rosa Minho dos, Gimenes, Bruna dos Passos, Studier, Nicole dos Santos

The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.