Title |
DNA-binding by Haemophilus influenzae and Escherichia coli YbaB, members of a widely-distributed bacterial protein family
|
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Published in |
BMC Microbiology, July 2009
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DOI | 10.1186/1471-2180-9-137 |
Pubmed ID | |
Authors |
Anne E Cooley, Sean P Riley, Keith Kral, M Clarke Miller, Edward DeMoll, Michael G Fried, Brian Stevenson |
Abstract |
Genes orthologous to the ybaB loci of Escherichia coli and Haemophilus influenzae are widely distributed among eubacteria. Several years ago, the three-dimensional structures of the YbaB orthologs of both E. coli and H. influenzae were determined, revealing a novel "tweezer"-like structure. However, a function for YbaB had remained elusive, with an early study of the H. influenzae ortholog failing to detect DNA-binding activity. Our group recently determined that the Borrelia burgdorferi YbaB ortholog, EbfC, is a DNA-binding protein. To reconcile those results, we assessed the abilities of both the H. influenzae and E. coli YbaB proteins to bind DNA to which B. burgdorferi EbfC can bind. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 40% |
Student > Doctoral Student | 3 | 9% |
Other | 2 | 6% |
Student > Bachelor | 2 | 6% |
Researcher | 2 | 6% |
Other | 5 | 14% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 49% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Immunology and Microbiology | 3 | 9% |
Social Sciences | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 20% |