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Mendeley readers
| Chapter title |
Probing Wnt Receptor Turnover: A Critical Regulatory Point of Wnt Pathway.
|
|---|---|
| Chapter number | 5 |
| Book title |
Wnt Signaling
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-6393-5_5 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6391-1, 978-1-4939-6393-5
|
| Authors |
Xiaomo Jiang, Feng Cong |
| Editors |
Quinn Barrett, Lawrence Lum |
| Abstract |
Wnt pathways are critical for embryonic development and adult tissue homeostasis in all multicellular animals. Many regulatory mechanisms exist to control proper signaling output. Recent studies suggest that cell surface Wnt receptor level is controlled by ubiquitination, and serve as a critical regulatory point of Wnt pathway activity as it determines the responsiveness of cells to Wnt signal. Here, we describe flow cytometry, cell surface protein biotinylation, and immunofluorescence pulse-chase methods to probe the surface expression, ubiquitination, and internalization of the Wnt receptors FZD and LRP6. |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 33% |
| Student > Ph. D. Student | 1 | 33% |
| Researcher | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 67% |
| Medicine and Dentistry | 1 | 33% |