Chapter title |
Injury Models of the Central Nervous System
|
---|---|
Chapter number | 35 |
Book title |
Injury Models of the Central Nervous System
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3816-2_35 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
|
Authors |
Shen, Qiang, Watts, Lora Tally, Li, Wei, Duong, Timothy Q, Qiang Shen Ph.D., Lora Tally Watts, Wei Li, Timothy Q. Duong Ph.D., Qiang Shen, Timothy Q. Duong |
Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
Abstract |
Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. Common causes of TBI include falls, violence, injuries from wars, and vehicular and sporting accidents. The initial direct mechanical damage in TBI is followed by progressive secondary injuries such as brain swelling, perturbed cerebral blood flow (CBF), abnormal cerebrovascular reactivity (CR), metabolic dysfunction, blood-brain-barrier disruption, inflammation, oxidative stress, and excitotoxicity, among others. Magnetic resonance imaging (MRI) offers the means to noninvasively probe many of these secondary injuries. MRI has been used to image anatomical, physiological, and functional changes associated with TBI in a longitudinal manner. This chapter describes controlled cortical impact (CCI) TBI surgical procedures, a few common MRI protocols used in TBI imaging, and, finally, image analysis pertaining to experimental TBI imaging in rats. |
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Mendeley readers
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