Chapter title |
Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury.
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Chapter number | 9 |
Book title |
Injury Models of the Central Nervous System
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-3816-2_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
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Authors |
Zaynab Jaber M.S., Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou-Abbass, Firas Kobeissy Ph.D., Zaynab Jaber, Firas Kobeissy |
Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
Abstract |
The application of systems biology tools in analyzing heterogeneous data from multiple sources has become a necessity, especially in biomarker discovery. Such tools were developed with several approaches to address different types of research questions and hypotheses. In the field of neurotrauma and traumatic brain injury (TBI), three distinct approaches have been used so far as systems biology tools, namely functional group categorization, pathway analysis, and protein-protein interaction (PPI) networks. The databases allow for query of the system to identify candidate targets which can be further studied to elucidate potential downstream biomarkers indicative of disease progression, severity, and improvement. The various systems biology tools, databases, and strategies that can be implemented on available TBI data in neuroproteomic studies are discussed in this chapter. |
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Mendeley readers
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Other | 3 | 25% |
Student > Ph. D. Student | 2 | 17% |
Researcher | 2 | 17% |
Professor | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |
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Biochemistry, Genetics and Molecular Biology | 3 | 25% |
Medicine and Dentistry | 3 | 25% |
Nursing and Health Professions | 1 | 8% |
Computer Science | 1 | 8% |
Engineering | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 25% |