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Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro

Overview of attention for article published in Molecules, September 2016
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Title
Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro
Published in
Molecules, September 2016
DOI 10.3390/molecules21091228
Pubmed ID
Authors

Muhammad Yusran Abdul Aziz, Nadiah Abu, Swee Keong Yeap, Wan Yong Ho, Abdul Rahman Omar, Nor Hadiani Ismail, Syahida Ahmad, Mehdi R. Pirozyan, Nadeem M. Akhtar, Noorjahan Banu Alitheen

Abstract

Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Student > Bachelor 8 15%
Student > Ph. D. Student 6 12%
Other 4 8%
Researcher 3 6%
Other 7 13%
Unknown 16 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 15%
Pharmacology, Toxicology and Pharmaceutical Science 7 13%
Agricultural and Biological Sciences 5 10%
Nursing and Health Professions 3 6%
Chemistry 3 6%
Other 7 13%
Unknown 19 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2016.
All research outputs
#17,534,407
of 25,707,225 outputs
Outputs from Molecules
#11,169
of 24,018 outputs
Outputs of similar age
#216,036
of 331,598 outputs
Outputs of similar age from Molecules
#113
of 241 outputs
Altmetric has tracked 25,707,225 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,018 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,598 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.