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The effects of mGlu7 receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains

Overview of attention for article published in Behavioural Pharmacology, April 2013
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Title
The effects of mGlu7 receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains
Published in
Behavioural Pharmacology, April 2013
DOI 10.1097/fbp.0b013e32835efc78
Pubmed ID
Authors

Richard M. O’Connor, John F. Cryan

Abstract

There is increasing evidence suggesting a role of the neurotransmitter glutamate in depression. The metabotropic glutamate (mGlu) receptors are G-protein coupled receptors, which mediate a slow modulatory response to glutamate signalling. mGlu₇ receptor is a presynaptic inhibitory autoreceptor showing great promise as a potential therapeutic target for the treatment of depression. Selective pharmacological modulators of mGlu₇ receptor have been developed; the positive allosteric modulator AMN082 and the negative modulator 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride (MMPIP). They remain to be extensively characterized in behavioural models sensitive to antidepressant action. Therefore, we assessed the effects of these compounds on behaviour in two different mouse strains using several preclinical tests sensitive to antidepressant pharmacological action. AMN082 (6 mg/kg) reduced immobility in the forced swim test and tail suspension test (TST) in both C57BL/6j and CD1 mice. In CD1 mice, MMPIP (10 and 30 mg/kg) significantly increased the time spent immobile in the TST, whereas this effect was restricted to a dose of 30 mg/kg in C57BL/6j mice. Administration of MMPIP with AMN082 partially attenuated the antidepressant-like effect of AMN082 in C57BL/6j mice in the forced swim test and the TST. However, this effect was absent from the CD1 strain. This further adds to the growing corpus of data promoting the targeting of mGlu₇ receptor with the aim of achieving an antidepressant effect.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Ireland 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 29%
Student > Bachelor 4 14%
Other 2 7%
Student > Master 2 7%
Researcher 2 7%
Other 3 11%
Unknown 7 25%
Readers by discipline Count As %
Neuroscience 5 18%
Agricultural and Biological Sciences 4 14%
Medicine and Dentistry 4 14%
Psychology 1 4%
Arts and Humanities 1 4%
Other 2 7%
Unknown 11 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2013.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Behavioural Pharmacology
#678
of 1,174 outputs
Outputs of similar age
#163,562
of 212,995 outputs
Outputs of similar age from Behavioural Pharmacology
#3
of 8 outputs
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So far Altmetric has tracked 1,174 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.