Daryl R Cheng, Hazel J Clothier, Hannah J Morgan, Emma Roney, Priya Shenton, Nicholas Cox, Bryn O Jones, Silja Schrader, Nigel W Crawford, Jim P Buttery, Greta Goldsmith, Samar Hikmat, Josh Osowicki, Linny Phuong, Mel Addison, Louise Dempsey, Adele Harris, Georgie Lewis, Bianca Penak, Laura Voss, Jaimee Craft, Victoria Scott, Lois Tham, Anna Power, Ngaree Blow, Elise Virah Sawmy, Eleanor Duckworth, Michelle Wolthuizen, Naveen Tenneti, Nick White, Melodie Heland, Sally Gordon, Jane Standish, Kathleen McCloskey, Brooke Doherty, Catie Fleming, Jeremy Carr, Matthew O’Brien, Paxton Loke, Ciara Earley, David Tran, Shane O’Dea, Lianne Cox, Yoko Asakawa, Teresa Lazzaro, Kirsten Perrett, Shidan Tosif, Wonie Uahwatanasakul
Abstract
COVID-19 mRNA vaccine-associated myocarditis has previously been described; however specific features in the adolescent population are currently not well understood.
To describe myocarditis adverse events following immunisation reported following any COVID-19 mRNA vaccines in the adolescent population in Victoria, Australia.
Statewide, population-based study.
Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC) is the vaccine-safety service for Victoria, Australia.
All SAEFVIC reports of myocarditis and myopericarditis in 12-17-year-old COVID-19 mRNA vaccinees submitted between 22 February 2021 and 22 February 2022, as well as accompanying diagnostic investigation results where available, were assessed using Brighton Collaboration criteria for diagnostic certainty.
Any mRNA COVID-19 vaccine.
Confirmed myocarditis as per Brighton Collaboration criteria (levels 1-3).
Clinical review demonstrated definitive (Brighton level 1) or probable (level 2) diagnoses in 75 cases. Confirmed myocarditis reporting rates were 8.3 per 100 000 doses in this age group. Cases were predominantly male (n=62, 82.7%) and post dose 2 (n=61, 81.3%). Rates peaked in the 16-17-year-old age group and were higher in males than females (17.7 vs 3.9 per 100 000, p=<0.001).The most common presenting symptoms were chest pain, dyspnoea and palpitations. A large majority of cases who had a cardiac MRI had abnormalities (n=33, 91.7%). Females were more likely to have ongoing clinical symptoms at 1-month follow-up (p=0.02).
Accurate evaluation and confirmation of episodes of COVID-19 mRNA vaccine-associated myocarditis enabled understanding of clinical phenotypes in the adolescent age group. Any potential vaccination and safety surveillance policies needs to consider age and gender differences.
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2024.
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#1,363,465
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Outputs from BMJ Paediatrics Open
#70
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#30,227
of 448,731 outputs
Outputs of similar age from BMJ Paediatrics Open
#3
of 23 outputs
Altmetric has tracked 26,793,225 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 794 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.
