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Oxidative stress and skeletal muscle dysfunction are present in healthy smokers

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2016
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Title
Oxidative stress and skeletal muscle dysfunction are present in healthy smokers
Published in
Brazilian Journal of Medical and Biological Research, January 2016
DOI 10.1590/1414-431x20165512
Pubmed ID
Authors

C.D.C. Neves, A.C.R. Lacerda, V.K.S. Lage, L.P. Lima, R. Tossige-Gomes, S.F. Fonseca, E. Rocha-Vieira, M.M. Teixeira, V.A. Mendonça

Abstract

Chronic exposure to cigarette smoke seems to be related to an increase of pro-inflammatory cytokines, oxidative stress and changes in muscular and physical performances of healthy smokers. However, these parameters have not yet been evaluated simultaneously in previous studies. The participants of this study were healthy males divided into two groups: smokers (n=20) and non-smokers (n=20). Inflammation was evaluated by measuring plasma levels of the cytokines IL-10, IL-6 e TNF-α, and of the soluble receptors sTNFR1 and sTNFR2. Oxidative stress was evaluated by determination of thiobarbituric acid reactive substances (TBARS) plasma levels, total antioxidant capacity of plasma and erythrocytes activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase. Muscular performance was evaluated by measuring the peak torque of knee flexors and extensors, and by determining the total work of the knee extensors. Physical performance was assessed by measuring the peak oxygen uptake (VO2 peak), the maximum heart rate (HRmax) and the walking distance in the shuttle walking test. Smokers showed an increase in the levels of the sTNFR1 and TBARS and a decrease in the total antioxidant capacity of plasma, in the catalase activity and in the total work (P<0.05). IL-6, IL-10, sTNFR2, SOD, peak torque, VO2 peak, HRmax and walking distance were similar between groups. Smokers presented increased oxidative stress and skeletal muscle dysfunction, demonstrating that the changes in molecular and muscular parameters occur simultaneously in healthy smokers.

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Mendeley readers

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Geographical breakdown

Country Count As %
Peru 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 16%
Researcher 9 16%
Student > Bachelor 8 14%
Student > Ph. D. Student 5 9%
Other 4 7%
Other 11 19%
Unknown 12 21%
Readers by discipline Count As %
Medicine and Dentistry 13 22%
Nursing and Health Professions 7 12%
Biochemistry, Genetics and Molecular Biology 7 12%
Agricultural and Biological Sciences 5 9%
Sports and Recreations 4 7%
Other 9 16%
Unknown 13 22%