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The CFTR M470V Gene Variant as a Potential Modifier of COPD Severity: Study of Serbian Population

Overview of attention for article published in Genetic Testing, September 2008
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

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28 patents
1 Facebook page


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The CFTR M470V Gene Variant as a Potential Modifier of COPD Severity: Study of Serbian Population
Published in
Genetic Testing, September 2008
DOI 10.1089/gte.2007.0069
Pubmed ID

Marija Stankovic, Aleksandra Nikolic, Aleksandra Divac, Andrija Tomovic, Natasa Petrovic-Stanojevic, Marina Andjelic, Vesna Dopudja-Pantic, Mirjana Surlan, Ivan Vujicic, Dimitrije Ponomarev, Marija Mitic-Milikic, Jelena Kusic, Dragica Radojkovic


Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by genetic and environmental factors. Cystic fibrosis transmembrane conductance regulator (CFTR) protein is an important component of the lung tissue homeostasis, involved in the regulation of the rate of mucociliary clearance. As it is known that certain CFTR variants have consequences on the function of CFTR protein, the aim of this study was to examine the possible role of F508del, M470V, Tn locus, and R75Q variants in COPD development and modulation. Total number of 86 COPD patients and 102 control subjects were included in the study. Possible association between COPD susceptibility, severity, and onset of the disease and allele or genotype of four analyzed CFTR variants was examined. No associations were detected between COPD development, onset of the disease and tested CFTR alleles and genotypes. However, VV470 genotype was associated with mild/moderate COPD stages in comparison to severe/very severe ones (OR = 0.29, 95%CI = 0.11-0.80, p = 0.016). Our study showed that patients with VV470 genotype had a 3.4-fold decreased risk for the appearance of severe/very severe COPD symptoms, and the obtained results indicate that this genotype may have a protective role. These results also suggest the importance of studying CFTR gene as a modifier of this disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Professor > Associate Professor 3 18%
Student > Ph. D. Student 3 18%
Other 2 12%
Student > Bachelor 2 12%
Other 1 6%
Unknown 2 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 29%
Biochemistry, Genetics and Molecular Biology 5 29%
Medicine and Dentistry 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Neuroscience 1 6%
Other 0 0%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
of 25,461,852 outputs
Outputs from Genetic Testing
of 698 outputs
Outputs of similar age
of 95,879 outputs
Outputs of similar age from Genetic Testing
of 4 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 698 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,879 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.