Chapter title |
Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs.
|
---|---|
Chapter number | 6 |
Book title |
Adhesion G Protein-coupled Receptors
|
Published in |
Handbook of experimental pharmacology, November 2016
|
DOI | 10.1007/978-3-319-41523-9_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-941521-5, 978-3-31-941523-9
|
Authors |
Ines Liebscher, Torsten Schöneberg, Liebscher, Ines, Schöneberg, Torsten |
Editors |
Tobias Langenhan, Torsten Schöneberg |
Abstract |
Adhesion GPCRs harbor a tethered agonist sequence (reproduced from [24]) As the past years have seen a magnificent increase in knowledge on adhesion GPCR (aGPCR) signal transduction, the time had come to fill the gap on how these receptors can be activated. Based on experimental observations that deletion of the ectodomain can induce signaling, the idea arose that aGPCRs, just like other atypical GPCRs, may harbor a tethered agonist sequence. In this chapter, we describe the recent findings and characteristics of this agonist, called the Stachel sequence, and discuss potential mechanisms that cause liberation of this encrypted sequence. Further, we provide perspectives for application of Stachel-derived synthetic peptides in future studies of aGPCR function. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 21% |
Researcher | 6 | 18% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Other | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
Agricultural and Biological Sciences | 3 | 9% |
Neuroscience | 3 | 9% |
Medicine and Dentistry | 2 | 6% |
Other | 0 | 0% |
Unknown | 10 | 30% |