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Aptamers as a promising approach for the control of parasitic diseases

Overview of attention for article published in Brazilian Journal of Infectious Diseases, October 2016
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Title
Aptamers as a promising approach for the control of parasitic diseases
Published in
Brazilian Journal of Infectious Diseases, October 2016
DOI 10.1016/j.bjid.2016.08.011
Pubmed ID
Authors

Juan David Ospina-Villa, Absalom Zamorano-Carrillo, Carlos A. Castañón-Sánchez, Esther Ramírez-Moreno, Laurence A. Marchat

Abstract

Aptamers are short single-stranded RNA or DNA oligonucleotides that are capable of binding various biological targets with high affinity and specificity. Their identification initially relies on a molecular process named SELEX (Systematic Evolution of Ligands by EXponential enrichment) that has been later modified in order to improve aptamer sensitivity, minimize duration and cost of the assay, as well as increase target types. Several biochemical modifications can help to enhance aptamer stability without affecting significantly target interaction. As a result, aptamers have generated a large interest as promising tools to compete with monoclonal antibodies for detection and inhibition of specific markers of human diseases. One aptamer-based drug is currently authorized and several others are being clinically evaluated. Despite advances in the knowledge of parasite biology and host-parasite interactions from "omics" data, protozoan parasites still affect millions of people around the world and there is an urgent need for drug target discovery and novel therapeutic concepts. In this context, aptamers represent promising tools for pathogen identification and control. Recent studies have reported the identification of "aptasensors" for parasite diagnosis, and "intramers" targeting intracellular proteins. Here we discuss various strategies that have been employed for intracellular expression of aptamers and expansion of their possible application, and propose that they may be suitable for the clinical use of aptamers in parasitic infections.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 9 15%
Student > Master 7 12%
Student > Bachelor 5 8%
Student > Postgraduate 4 7%
Other 8 14%
Unknown 15 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 25%
Agricultural and Biological Sciences 8 14%
Chemistry 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Medicine and Dentistry 2 3%
Other 9 15%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2016.
All research outputs
#21,077,590
of 25,887,951 outputs
Outputs from Brazilian Journal of Infectious Diseases
#546
of 816 outputs
Outputs of similar age
#253,098
of 327,296 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#9
of 17 outputs
Altmetric has tracked 25,887,951 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 816 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.