Thanyanan Chaowanachan, Emily Krogstad, Cameron Ball, Kim A. Woodrow
Abstract
The use of drug combinations has revolutionized the treatment of HIV but there is no equivalent combination product that exists for prevention, particularly for topical HIV prevention. Strategies to combine chemically incompatible agents may facilitate the discovery of unique drug-drug activities, particularly unexplored combination drug synergy. We fabricated two types of nanoparticles, each loaded with a single antiretroviral (ARV) that acts on a specific step of the viral replication cycle. Here we show unique combination drug activities mediated by our polymeric delivery systems when combined with free tenofovir (TFV).
Pharmacology, Toxicology and Pharmaceutical Science
10
16%
Chemistry
7
11%
Medicine and Dentistry
7
11%
Biochemistry, Genetics and Molecular Biology
4
6%
Agricultural and Biological Sciences
4
6%
Other
14
23%
Unknown
16
26%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2013.
All research outputs
#8,178,511
of 26,367,306 outputs
Outputs from PLOS ONE
#113,165
of 229,485 outputs
Outputs of similar age
#64,288
of 211,300 outputs
Outputs of similar age from PLOS ONE
#1,767
of 5,031 outputs
Altmetric has tracked 26,367,306 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 229,485 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,300 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 5,031 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
