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Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats

Overview of attention for article published in Nutrition, September 2016
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Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats
Published in
Nutrition, September 2016
DOI 10.1016/j.nut.2016.08.006
Pubmed ID

Nor Aijratul Asikin Mohd Shalan, Noordin M. Mustapha, Suhaila Mohamed


Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders. Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats. Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh). The water extracts (dose-dependently for noni leaves) increased bone regeneration biomarker (runt-related transcription factor 2, bone morphogenetic protein 2, osteoprotegerin, estrogen receptor 1 [ESR1], collagen type I alpha 1A) expressions and reduced the inflammatory biomarkers (interleukin-6, tumor necrosis factor-α, nuclear factor [NF]-κB, and receptor activator of NF-κB ligand) mRNA expressions/levels in the rats. The extracts also improved bone physical and mechanical properties. The extracts demonstrated bone regeneration through improving bone size and structure, bone mechanical properties (strength and flexibility), and bone mineralization and density. The catechin-rich extract favored bone regeneration and suppressed bone resorption. The mechanisms involved enhancing osteoblast generation and survival, inhibiting osteoclast growth and activities, suppressing inflammation, improving bone collagen synthesis and upregulating ESR1 expression to augment phytoestrogenic effects. Estrogen deficiency bone loss and all extracts studied (best effect from Morinda leaf at 300 mg/kg body weight) mitigated the loss, indicating benefits for the aged and menopausal women.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 19%
Student > Master 10 12%
Student > Ph. D. Student 8 9%
Researcher 4 5%
Student > Doctoral Student 2 2%
Other 8 9%
Unknown 38 44%
Readers by discipline Count As %
Nursing and Health Professions 9 10%
Biochemistry, Genetics and Molecular Biology 8 9%
Medicine and Dentistry 7 8%
Agricultural and Biological Sciences 5 6%
Psychology 4 5%
Other 11 13%
Unknown 42 49%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2020.
All research outputs
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Outputs from Nutrition
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Outputs of similar age
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Outputs of similar age from Nutrition
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Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,244 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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