Chapter title |
Mechanisms of Vertebrate Germ Cell Determination.
|
---|---|
Chapter number | 8 |
Book title |
Vertebrate Development
|
Published in |
Advances in experimental medicine and biology, December 2016
|
DOI | 10.1007/978-3-319-46095-6_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-946093-2, 978-3-31-946095-6
|
Authors |
Tristan Aguero, Susannah Kassmer, Ramiro Alberio, Andrew Johnson, Mary Lou King |
Editors |
Francisco Pelegri, Michael Danilchik, Ann Sutherland |
Abstract |
Two unique characteristics of the germ line are the ability to persist from generation to generation and to retain full developmental potential while differentiating into gametes. How the germ line is specified that allows it to retain these characteristics within the context of a developing embryo remains unknown and is one focus of current research. Germ cell specification proceeds through one of two basic mechanisms: cell autonomous or inductive. Here, we discuss how germ plasm driven germ cell specification (cell autonomous) occurs in both zebrafish and the frog Xenopus. We describe the segregation of germ cells during embryonic development of solitary and colonial ascidians to provide an evolutionary context to both mechanisms. We conclude with a discussion of the inductive mechanism as exemplified by both the mouse and axolotl model systems. Regardless of mechanism, several general themes can be recognized including the essential role of repression and posttranscriptional regulation of gene expression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 21% |
Researcher | 6 | 16% |
Student > Bachelor | 4 | 11% |
Professor | 4 | 11% |
Other | 2 | 5% |
Other | 4 | 11% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 34% |
Agricultural and Biological Sciences | 8 | 21% |
Medicine and Dentistry | 2 | 5% |
Environmental Science | 2 | 5% |
Arts and Humanities | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 26% |