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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heme Iron from Meat and Risk of Colorectal Cancer: A Meta-analysis and a Review of the Mechanisms Involved
|
|---|---|
| Published in |
Cancer Prevention Research, February 2011
|
| DOI | 10.1158/1940-6207.capr-10-0113 |
| Pubmed ID | |
| Authors |
Nadia M. Bastide, Fabrice H.F. Pierre, Denis E. Corpet |
| Abstract |
Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer. This meta-analysis of prospective cohort studies of colon cancer reporting heme intake included 566,607 individuals and 4,734 cases of colon cancer. The relative risk of colon cancer was 1.18 (95% CI: 1.06-1.32) for subjects in the highest category of heme iron intake compared with those in the lowest category. Epidemiological data thus show a suggestive association between dietary heme and risk of colon cancer. The analysis of experimental studies in rats with chemically-induced colon cancer showed that dietary hemoglobin and red meat consistently promote aberrant crypt foci, a putative precancer lesion. The mechanism is not known, but heme iron has a catalytic effect on (i) the endogenous formation of carcinogenic N-nitroso compounds and (ii) the formation of cytotoxic and genotoxic aldehydes by lipoperoxidation. A review of evidence supporting these hypotheses suggests that both pathways are involved in heme iron toxicity. |
X Demographics
The data shown below were collected from the profiles of 114 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 11% |
| United Kingdom | 12 | 11% |
| Canada | 6 | 5% |
| Japan | 2 | 2% |
| Iceland | 2 | 2% |
| France | 2 | 2% |
| Argentina | 2 | 2% |
| Mexico | 2 | 2% |
| Germany | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 65 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 100 | 88% |
| Practitioners (doctors, other healthcare professionals) | 10 | 9% |
| Scientists | 3 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 413 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Bulgaria | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 409 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 82 | 20% |
| Student > Master | 63 | 15% |
| Student > Ph. D. Student | 50 | 12% |
| Researcher | 44 | 11% |
| Student > Postgraduate | 23 | 6% |
| Other | 62 | 15% |
| Unknown | 89 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 79 | 19% |
| Medicine and Dentistry | 75 | 18% |
| Biochemistry, Genetics and Molecular Biology | 44 | 11% |
| Nursing and Health Professions | 32 | 8% |
| Chemistry | 12 | 3% |
| Other | 63 | 15% |
| Unknown | 108 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 196. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2024.
All research outputs
#205,890
of 25,758,695 outputs
Outputs from Cancer Prevention Research
#29
of 1,460 outputs
Outputs of similar age
#816
of 195,405 outputs
Outputs of similar age from Cancer Prevention Research
#2
of 23 outputs
Altmetric has tracked 25,758,695 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,460 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,405 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.