| Chapter title |
Prediction of Protein Interactions by Structural Matching: Prediction of PPI Networks and the Effects of Mutations on PPIs that Combines Sequence and Structural Information
|
|---|---|
| Chapter number | 12 |
| Book title |
Protein Bioinformatics
|
| Published in |
Methods in molecular biology, February 2017
|
| DOI | 10.1007/978-1-4939-6783-4_12 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6781-0, 978-1-4939-6783-4
|
| Authors |
Nurcan Tuncbag, Ozlem Keskin, Ruth Nussinov, Attila Gursoy |
| Editors |
Cathy H. Wu, Cecilia N. Arighi, Karen E. Ross |
| Abstract |
Structural details of protein interactions are invaluable to the understanding of cellular processes. However, the identification of interactions at atomic resolution is a continuing challenge in the systems biology era. Although the number of structurally resolved complexes in the Protein Databank increases exponentially, the complexes only cover a small portion of the known structural interactome. In this chapter, we review the PRISM system that is a protein-protein interaction (PPI) prediction tool-its rationale, principles, and applications. We further discuss its extensions to discover the effect of single residue mutations, to model large protein assemblies, to improve its performance by exploiting conformational protein ensembles, and to reconstruct large PPI networks or pathway maps. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 4% |
| Unknown | 24 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 32% |
| Student > Bachelor | 5 | 20% |
| Professor | 3 | 12% |
| Researcher | 3 | 12% |
| Other | 2 | 8% |
| Other | 1 | 4% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 36% |
| Chemistry | 3 | 12% |
| Agricultural and Biological Sciences | 3 | 12% |
| Computer Science | 2 | 8% |
| Earth and Planetary Sciences | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 24% |