| Chapter title |
Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond
|
|---|---|
| Chapter number | 4 |
| Book title |
Cancer and Zebrafish
|
| Published in |
Advances in experimental medicine and biology, May 2016
|
| DOI | 10.1007/978-3-319-30654-4_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
| Authors |
Jeroen den Hertog |
| Editors |
David M. Langenau |
| Abstract |
Zebrafish are increasingly being used to study cancer. Almost all tumor types have been found in zebrafish. However, tumor incidence is relatively low and tumors develop late in life. Functional inactivation of tumor suppressors is a crucial step in cancer progression and more and more tumor suppressor genes are being studied in zebrafish. Most often tumor suppressors have been inactivated by reverse genetics approaches using targeted disruption. However, some tumor suppressor mutants were identified by forward genetic screens for mutants with a particular phenotype. Some of the latter genes had not been recognized as tumor suppressors yet. Similarly, a screen for genes that suppress tumor formation in zebrafish in vivo led to the identification of a novel tumor suppressor gene. In this review, I will provide an overview of what the zebrafish has taught us about tumor suppressors. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 33% |
| Professor | 3 | 17% |
| Student > Bachelor | 2 | 11% |
| Student > Master | 1 | 6% |
| Researcher | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 39% |
| Agricultural and Biological Sciences | 5 | 28% |
| Linguistics | 1 | 6% |
| Unknown | 5 | 28% |